Evidence map›Paper›PMID 41106389›Full record

ArticleStem cell reports2025

Human adrenocortical organoids for tissue regeneration and disease modeling.

Qing Li, Xiaoyu Li, Yiming Zhang, Yanting Shen, Zhiqiang Lu, Wei Chen, Yujun Liu, Shuang Wu, Xiaofeng Gong, Xuewen Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qing LiSchool of Basic Medical Sciences, Institute of Biomedical Innovation, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
Xiaoyu LiSchool of Basic Medical Sciences, Institute of Biomedical Innovation, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
Yiming ZhangSchool of Basic Medical Sciences, Institute of Biomedical Innovation, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.
Yanting ShenDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Zhiqiang LuDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Wei ChenDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yujun LiuDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Shuang WuZ Lab, BioGenous BIOTECH, Shanghai 200438, China.
Xiaofeng GongZ Lab, BioGenous BIOTECH, Shanghai 200438, China.
Xuewen LiZ Lab, BioGenous BIOTECH, Shanghai 200438, China.
Nicole BechmannInstitute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
Jingjing JiangDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: jiang.jingjing@zs-hospital.sh.cn.
Bing ZhaoSchool of Basic Medical Sciences, Institute of Biomedical Innovation, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330031, China; Z Lab, BioGenous BIOTECH, Shanghai 200438, China. Electronic address: bingzhao@ncu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adrenal glands are essential endocrine organs that secrete key hormones maintaining physiological homeostasis. Herein, we established expandable three-dimensional (3D) human adrenocortical organoid (ACO) cultures that preserved the characteristic of zona fasciculata cell lineages and retained their capacity to produce cortisol. The ACOs could secrete glucocorticoids in response to physiological stimuli and thus rescue adrenalectomized mice, indicating their potential for the treatment of primary adrenal insufficiency. Furthermore, by introducing a hotspot pathogenic variant (PRKACA L206R) identified in Cushing's syndrome, we achieved the organoid disease modeling of cortisol-producing adenomas. In summary, this study establishes a human organoid platform to explore homeostasis and dysfunction in adrenal glands, suggesting future applications in disease modeling and regenerative medicine.

Indexed as

Adrenal CortexOrganoidsRegenerationAnimalsDisease Models, AnimalHumansHydrocortisoneMiceHydrocortisoneadrenal insufficiencyadrenal regenerationadrenocortical adenomahuman adrenocortical organoidsPRKACA L206R

Identifiers

PMID41106389
PMCPMC12790718

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.