ArticleNeuropeptides2025
Ultrastructural characterization of neuropeptide Y synapses in the central inferior colliculus of the Fischer Brown Norway rat.
Article in Neuropeptides, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Molecular taxonomy and spatial organization define neuronal subtypes in the mouse inferior colliculus.iScience · 2026Article
- Age-related differences in asymmetric synapses across the central inferior colliculus in the Fischer Brown Norway rat.Aging brain · 2026Article
- Ultrastructural Synaptic Differences in the Central Inferior Colliculus in the 3xTG Mouse Across Three Disease Stages.The Journal of comparative neurology · 2025Article
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8 authors.
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Abstract
introductionThe central nucleus of the inferior colliculus (ICc) is the primary target for ascending auditory projections from the lower auditory brainstem nuclei and the main source of ascending projections to the auditory thalamus. The ICc has an extensive network of tonotopically organized neurons, whose classification is a subject of broad interest. In order to understand the extensive microcircuitry of the ICc, it is important to ascertain the synaptic arrangements among molecularly identified neuronal populations. The objective of this study was to describe inhibitory Neuropeptide Y (NPY) synapses in the central nucleus of the IC.
methodWe used electron microscopy (EM) and post-embedding anti-NPY immunogold histochemistry on tissue from adult Fischer Brown Norway rats. Inhibitory NPY synapses were identified by pleomorphic vesicles, symmetric synaptic junctions, and NPY-immunopositive presynaptic boutons.
resultsThe data demonstrate that NPY terminals largely (∼75 %) form symmetric synapses with pleomorphic vesicles, mostly target small and medium dendrites, and have larger average bouton areas, active zone lengths, and vesicle pools, as compared to the overall GABAergic population. DISCUSSION: The subset of GABAergic neurons that co-express NPY feature synaptic characteristics suggesting that NPY neuromodulation has a widespread role in regulating excitation in the ICc.
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