Evidence map›Paper›PMID 41105922›Full record

ArticleThe FEBS journal2026

Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor-like lectin.

Filip Melicher, Pavel Dobeš, Jan Komárek, Lukáš Faltinek, Marek Korsák, Petra Sýkorová, Josef Houser, Michaela Wimmerová

Abstract read
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In one paragraph

Article in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Filip MelicherCentral European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Pavel DobešNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic.ORCID 0000-0003-1699-0849
Jan KomárekCentral European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Lukáš FaltinekDepartment of Biochemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.
Marek KorsákCentral European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Petra SýkorováCentral European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Josef HouserCentral European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Michaela WimmerováCentral European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.ORCID 0000-0002-7108-4198

Funding

CALIPSOplus 730872Grantová Agentura České Republiky 21-29622SMinisterstvo Školství, Mládeže a Tělovýchovy LM2023042
6 · The paper itself

Abstract

Photorhabdus bacteria live in mutualistic relationships with Heterorhabditis nematodes, and together, they act as effective insect pathogens. These bacteria produce a diverse array of lectins, sugar-binding proteins that are believed to play crucial roles in the complex tripartite interaction among Photorhabdus, nematodes, and their insect hosts. One such lectin, Photorhabdus laumondii tumor necrosis factor (TNF)-like lectin (PLTL), identified in Photorhabdus laumondii subsp. laumondii TTO1, exhibits notable sequence similarity to the N-terminal domain of the BC2L-C lectin (BC2L-CN), a TNF-like lectin recognized for its specificity toward fucosylated glycans associated with human embryonic stem cells and certain cancers. Through glycan array analysis and surface plasmon resonance, we identified PLTL's binding preference for branched histo-blood group oligosaccharides. The crystallographic structure of PLTL in complex with the BLe

Indexed as

Bacterial ProteinsLectinsPhotorhabdusAmino Acid SequenceAnimalsCrystallography, X-RayHumansModels, MolecularPolysaccharidesProtein BindingSurface Plasmon ResonanceBacterial ProteinsLectinsPolysaccharidescarbohydrate recognitioncrystal structureglycan bindingHeterorhabditis bacteriophoraLectinLewis antigenPhotorhabdus laumondiiTNF fold

Identifiers

PMID41105922
PMCPMC12914763

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.