ArticleNeurology2025
Mapping the Association of Cerebral Small Vessel Disease, Gray Matter Integrity, and Cognitive Function.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- A composite measure of cerebral small vessel disease predicts cognitive change after stroke.medRxiv : the preprint server for health sciences · 2026Article
- The enigma of vascular dementia: current state and emerging perspectives.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
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Authors and funding
12 authors.
Funding
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Abstract
BACKGROUND AND
objectivesCerebral small vessel disease (CSVD) is associated with an increased risk of cognitive impairment and dementia. While its impact on white matter is well documented, CSVD-related gray matter alterations are less understood. In this work, we aimed to investigate the association between CSVD burden, regional gray matter integrity, and cognitive function in a large population-based cohort.
methodsWe examined participants from the Hamburg City Health Study, who underwent multidomain neuropsychological testing and multimodal neuroimaging. A composite CSVD burden score was calculated by aggregating the white matter hyperintensity load, Fazekas score, perivascular space (PVS) count, and peak width of skeletonized mean diffusivity (PSMD). Advanced imaging techniques based on T1-weighted, fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted MRI were leveraged to assess the integrity of cortical and subcortical gray matter, including the hippocampus. General cognitive ability (g) was derived by a principal component analysis of cognitive test scores.
resultsData from 2,603 participants (median age 65 years [interquartile range 14], 44.0% female) were analyzed. Higher CSVD burden was significantly associated with regionally specific gray matter abnormalities after family-wise error correction (family-wise error-corrected DISCUSSION: Complementing previous research that focuses on CSVD and white matter changes, our study highlights abnormal gray matter integrity as a possible link between small vessel pathology and cognitive disorders.
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