ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Dental stem cells (DSCs) hold immense potential in regenerative medicine due to their unique properties, including superior proliferative and differentiation capacities, robust immunomodulatory functions, and resilience to aging. However, the aging process profoundly impairs their functionality, diminishing their regenerative potential and limiting their clinical utility. This review provides a systematic examination of the mechanisms underlying DSC aging, focusing on disrupted signaling pathways, metabolic dysregulation, and epigenetic modifications, as well as the regulatory roles of non-coding RNAs and critical proteins. It further investigates the key intrinsic and extrinsic factors driving this process, offering a comprehensive perspective on the interplay between cellular and systemic influences. Building on this foundation, the review explores innovative strategies to mitigate age-related decline in DSCs, emphasizing approaches that target the extracellular matrix, mitochondrial dysfunction, and key molecular pathways. Finally, it addresses the challenges in translating these findings into clinical applications, such as inter-individual variability and systemic influences, and advocates for multidisciplinary approaches to enhance therapeutic outcomes. Collectively, this review provides a critical framework for advancing the clinical translation of DSC-based therapies, with broader implications for regenerative medicine in aging contexts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.