Evidence map›Paper›PMID 41105805›Full record

ArticleEpigenetics2025

Identification of blood-derived DNA methylation biomarkers of glaucoma and intraocular pressure measurements in three European ancestry cohorts including the Canadian longitudinal study on aging.

Xiaofan Jiang, Omar A Mahroo, Anthony P Khawaja, Dorota Skowronska-Krawczyk, David A Mackey, Janey L Wiggs, Christopher J Hammond, Pirro G Hysi, Christopher G Bell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaofan JiangDepartment of Twin Research and Genetic Epidemiology, St Thomas' Hospital Campus, King's College London, London, UK.ORCID 0000-0003-0951-1256
Omar A MahrooDepartment of Twin Research and Genetic Epidemiology, St Thomas' Hospital Campus, King's College London, London, UK.ORCID 0000-0003-1254-0832
Anthony P KhawajaFaculty of Brain Sciences, UCL Institute of Ophthalmology, London, UK.ORCID 0000-0001-6802-8585
Dorota Skowronska-KrawczykDepartment of Ophthalmology, Center for Translational Vision Research, School of Medicine, UC Irvine, Irvine, CA, USA.
David A MackeyCentre for Ophthalmology and Visual Science (Incorporating the Lions Eye Institute), The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0001-7914-4709
Janey L WiggsDepartment of Ophthalmology, Harvard Medical School, Boston, MA, USA.
Christopher J HammondDepartment of Twin Research and Genetic Epidemiology, St Thomas' Hospital Campus, King's College London, London, UK.
Pirro G HysiDepartment of Twin Research and Genetic Epidemiology, St Thomas' Hospital Campus, King's College London, London, UK.ORCID 0000-0001-5752-2510
Christopher G BellWilliam Harvey Research Institute, Barts & The London Faculty of Medicine and Dentistry, Charterhouse Square, Queen Mary University of London, London, UK.ORCID 0000-0003-4601-1242

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Creating a National Resource for Genetic Research in Behavioral & Health SciencesRC2AG036495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2009 to 2010
$7.4M
Expanding a National Resource for Genetic Research in Behavioral & Health ScienceRC4AG039029 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2010 to 2010
$6.0M
NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS U01 AG009740Wellcome Trust
6 · The paper itself

Abstract

Glaucoma is a major cause of blindness globally and its prevalence rises with age. This study explored systemic blood-derived DNA methylation epigenetic biomarkers for association with glaucoma and intraocular pressure (IOP). Blood-derived DNA methylation (DNAm) was analyzed in 1,201 European participants from the Canadian Longitudinal Study on Aging (CLSA; Illumina EPIC v1 array) and 843 European participants from TwinsUK (450k array). An Epigenome-Wide Association Study (EWAS) for glaucoma and IOP was conducted, adjusting for age, sex, tobacco smoking, and leukocyte cell types. DNAm-based EpiScores estimates for 108 plasma protein levels were evaluated for associations with glaucoma and IOP. Additionally, 'biological' age acceleration, estimated using five established DNAm 'clocks,' was assessed for glaucoma and IOP and replicated in The Health and Retirement Study (HRS;

Indexed as

AgingDNA MethylationGlaucomaIntraocular PressureAgedAged, 80 and overBiomarkersCanadaEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansLongitudinal StudiesMaleMiddle AgedWhite PeopleBiomarkersbiomarkersCLSADNA methylationEpigeneticsGlaucomaintraocular pressure

Identifiers

PMID41105805
PMCPMC12536625

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.