Evidence map›Paper›PMID 41105775›Full record

ArticleScience advances2025

Cooperative role of distinctive TP53 and PTEN combined loss in the peripheral T cell lymphoma-GATA3 molecular subgroup.

Waseem G Lone, Jiayu Yu, Xuxiang Liu, Dylan T Jochum, Alyssa Bouska, Kunal Shetty, Tyler Herek, Sunandini Sharma, Chengfeng Bi, Rauf Shah and 22 more

Erratum issuedAbstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Waseem G LoneDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-3078-614X
Jiayu YuDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.
Xuxiang LiuDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-1677-0814
Dylan T JochumDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-2750-6741
Alyssa BouskaDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-1324-6678
Kunal ShettyDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0003-1065-2734
Tyler HerekDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.
Sunandini SharmaDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.
Chengfeng BiDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0001-5375-7515
Rauf ShahDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-5779-154X
Zaina W NasserDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.
Catalina AmadorDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-0352-5526
Aiza ArifDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.
Abdul Rouf MirDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-2897-4419
Yuping LiDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, USA.
Tayla B Heavican-ForalDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jacob RobinsonDepartment of Biology, University of Nebraska at Omaha, Omaha, NE, USA.
R Katherine HydeDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-2808-1749
Mamiko Sakata-YanagimotoDivision of Advanced Hemato-Oncology, Transborder Medical Research Center, University of Tsukuba, Tsukuba, Japan.ORCID 0000-0001-7310-8045
Satyanarayana RachaganiDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-3949-8566
Timothy W McKeithanDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0003-2242-3074
David W ScottBritish Columbia Cancer, Vancouver, BC V5Z 4E6, Canada.ORCID 0000-0002-0435-5947
Louis M StaudtLymphoid Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1735-2892
Giorgio InghiramiDepartment of Pathology and Laboratory Medicine, Weil Cornell Medical College, New York, NY, USA.
Andrew FeldmanDepartment of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA.ORCID 0000-0001-5009-4808
Timothy GreinerDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-1470-8328
Julie M VoseDivision of Hematology and Oncology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-1015-7434
Lisa RimszaDepartment of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Scottsdale, AZ, USA.
Joesph KhouryDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-2621-3584
Wing C ChanDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, USA.ORCID 0000-0002-6243-6008
Javeed IqbalDepartment of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0003-3668-0629
Lymphoma/Leukemia Molecular Profiling Project (LLMPP)

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
Preclinical Models and Therapeutics CoreP01CA229100 · NCI · MAYO CLINIC ARIZONA · PI INGHIRAMI, GIORGIO · 2018 to 2022
$10.2M
CHEMICAL CARCINOGENESIS &CANCER BIOLOGYT32CA009476 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Jennifer D. Black · 1988 to 2026
$6.2M
The Role of the CBFB-MYH11 Complex in Leukemia MaintenanceR01CA244900 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HYDE, RICIA KATHERINE · 2020 to 2024
$1.9M
Pre-analytical variables of bioanalytes affecting the accuracy of PTCL diagnostic and prognostic genetic signaturesU01CA253218 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI IQBAL, JAVEED, MURTAZA, MUHAMMED · 2021 to 2025
$1.8M
NCI NIH HHS P01 CA229100NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA244900NCI NIH HHS T32 CA009476NCI NIH HHS U01 CA253218
6 · The paper itself

Abstract

Peripheral T cell lymphoma (PTCL) is a heterogeneous group of postthymic T cell neoplasms, with ~40% classified as PTCL-not otherwise specified (PTCL-NOS). PTCL-GATA3, a molecularly defined subtype, associated with T helper 2 (T

Indexed as

GATA3 Transcription FactorLymphoma, T-Cell, PeripheralPTEN PhosphohydrolaseTumor Suppressor Protein p53AnimalsCD4-Positive T-LymphocytesGene Expression Regulation, NeoplasticHumansMiceMutationGATA3 protein, humanGATA3 Transcription FactorPTEN PhosphohydrolasePTEN protein, humanTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID41105775
PMCPMC12533597

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.