Evidence map›Paper›PMID 41105772›Full record

ArticleScience advances2025

Ultrafast, remote-controlled protonation reaction enables structural changes in a phytochrome.

Madan Kumar Shankar, Lukas Grunewald, Weixiao Yuan Wahlgren, Brigitte Stucki-Buchli, Amke Nimmrich, Moona Kurttila, Anna-Lena Fischer, Giacomo Salvadori, Andrea Cellini, Piotr Maj and 18 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Madan Kumar ShankarDepartment of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.ORCID 0000-0002-7944-1081
Lukas GrunewaldDepartment of Chemistry - BMC, Biochemistry, Uppsala University, 75123 Uppsala, Sweden.ORCID 0009-0006-2976-8680
Weixiao Yuan WahlgrenDepartment of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.ORCID 0000-0003-0413-165X
Brigitte Stucki-BuchliNanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, 40014 Jyväskylä, Finland.ORCID 0000-0002-6756-0665
Amke NimmrichDepartment of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.ORCID 0000-0003-0425-2101
Moona KurttilaNanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, 40014 Jyväskylä, Finland.
Anna-Lena FischerDepartment of Chemistry - BMC, Biochemistry, Uppsala University, 75123 Uppsala, Sweden.ORCID 0009-0009-3310-5021
Giacomo SalvadoriInstitute for Computational Biomedicine (INM-9), Forschungszentrum Jülich, 52428 Jülich, Germany.ORCID 0000-0001-7330-6228
Andrea CelliniDepartment of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.
Piotr MajDepartment of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.ORCID 0000-0002-9832-2344
Atsarina Larasati AnindyaDepartment of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.
Elin ClaessonDepartment of Chemistry and Molecular Biology, University of Gothenburg, 40530 Gothenburg, Sweden.ORCID 0000-0001-8232-7725
Fangjia LuoRIKEN SPring-8 Center, Sayo, Hyogo, Japan.ORCID 0000-0003-0631-6236
Tek Narsingh MallaPhysics Department, University of Wisconsin-Milwaukee, 3135 North Maryland Avenue, Milwaukee, WI 53211, USA.ORCID 0000-0002-1387-0801
Suraj PandeyPhysics Department, University of Wisconsin-Milwaukee, 3135 North Maryland Avenue, Milwaukee, WI 53211, USA.ORCID 0000-0002-7097-2185
Takehiko ToshaRIKEN SPring-8 Center, Sayo, Hyogo, Japan.ORCID 0000-0002-8971-0759
Nuemket NipawanRIKEN SPring-8 Center, Sayo, Hyogo, Japan.
Shigeki OwadaRIKEN SPring-8 Center, Sayo, Hyogo, Japan.ORCID 0000-0002-1451-7612
Kensuke TonoRIKEN SPring-8 Center, Sayo, Hyogo, Japan.ORCID 0000-0003-1218-3759
Rie TanakaRIKEN SPring-8 Center, Sayo, Hyogo, Japan.ORCID 0000-0003-1062-4792
Emina A StojkovićDepartment of Biology, Northeastern Illinois University, 5500 North St. Louis Avenue, Chicago, IL 60625, USA.ORCID 0000-0002-4971-5213
Dmitry MozorovNanoscience Center, Department of Chemistry, University of Jyväskylä, 40014 Jyväskylä, Finland.ORCID 0000-0001-9524-948X
Pasi MyllyperkiöNanoscience Center, Department of Chemistry, University of Jyväskylä, 40014 Jyväskylä, Finland.ORCID 0000-0003-1651-1676
Tatu KumpulainenNanoscience Center, Department of Chemistry, University of Jyväskylä, 40014 Jyväskylä, Finland.ORCID 0000-0001-9469-9294
Heikki TakalaNanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, 40014 Jyväskylä, Finland.ORCID 0000-0003-2518-8583
Marius SchmidtPhysics Department, University of Wisconsin-Milwaukee, 3135 North Maryland Avenue, Milwaukee, WI 53211, USA.ORCID 0000-0002-0962-9468
Janne A IhalainenNanoscience Center, Department of Biological and Environmental Science, University of Jyväskylä, 40014 Jyväskylä, Finland.ORCID 0000-0002-8741-1587
Sebastian WestenhoffScience for Life Laboratory and Center for Chemical Mechanisms of Life, Department of Chemistry - BMC, Biochemistry, Uppsala University, 75123 Uppsala, Sweden.ORCID 0000-0002-6961-8015

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In photoactive proteins, coupling between the chromophore and protein matrix is exquisitely tuned. Proton transfer reactions can mediate this coupling, as in proton-coupled electron transfer and excited-state proton transfer. Additional mechanisms involving proton dislocations may exist but remain undiscovered. Here, we present a femtosecond crystallographic movie of the phytochrome from

Indexed as

Bacterial ProteinsDeinococcusPhytochromeProtonsCrystallography, X-RayHydrogen BondingModels, MolecularProtein ConformationBacterial ProteinsPhytochromeProtons

Identifiers

PMID41105772
PMCPMC12533598

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.