Evidence map›Paper›PMID 41105759›Full record

ArticleScience advances2025

Kinesin-1 coordinates cross-talk between microtubule and actin cytoskeletons during dendritic cell migration.

Pierre Duquesne, Céline Aoun, Mathieu Kurowska, Brieuc P Perot, Kerui Zhang, Mounia Debili, Mirjana Weimershaus, François-Xavier Mauvais, Nicolas Cagnard, Nicolas Goudin and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Pierre DuquesneUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.ORCID 0009-0001-2299-5657
Céline AounUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.ORCID 0009-0003-5075-074X
Mathieu KurowskaUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.ORCID 0000-0003-0154-0079
Brieuc P PerotUniversité Paris Cité, Imagine Institute, Laboratory of Single-Cell Inflammatory Responses and Multi-OMICs Networks, INSERM UMR1163, F-75015 Paris, France.ORCID 0000-0002-4672-9943
Kerui ZhangUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.
Mounia DebiliUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.
Mirjana WeimershausInstitute of Functional Genomics (IGF), CNRS UMR 5203, INSERM U1191, Université de Montpellier, Montpellier, France.ORCID 0000-0003-2874-6608
François-Xavier MauvaisUniversité Paris Cité, INSERM UMR1141, NeuroDiderot, Institut Hospitalo-Universitaire Robert-Debré du Cerveau de l'Enfant, Paris, France.ORCID 0000-0002-5240-4280
Nicolas CagnardStructure Fédérative de Recherche Necker, INSERM US24/CNRS UAR3633, Université Paris Cité, Institut Imagine, F-75015 Paris, France.ORCID 0000-0002-9051-1896
Nicolas GoudinStructure Fédérative de Recherche Necker, INSERM US24/CNRS UAR3633, Université Paris Cité, Institut Imagine, F-75015 Paris, France.ORCID 0000-0002-3967-4016
Bernardita MedelUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.ORCID 0009-0006-9849-4214
Juan Eduardo Montero-HermándezUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.ORCID 0000-0003-1158-6978
Linda DiedhiouUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.
Jian-Dong HuangSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.ORCID 0000-0001-7531-2816
Alain FischerUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.
Geneviève de Saint BasileUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.
Mickaël M MénagerUniversité Paris Cité, Imagine Institute, Laboratory of Single-Cell Inflammatory Responses and Multi-OMICs Networks, INSERM UMR1163, F-75015 Paris, France.ORCID 0000-0002-6838-2389
Pablo VargasLeukomotion Lab, Paris Cité University, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, F-75015 Paris, France.ORCID 0000-0002-6475-494X
Fernando E SepulvedaUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.ORCID 0000-0001-5865-4929
Gaël MénaschéUniversité Paris Cité, Imagine Institute, Laboratory of Molecular Basis of Altered Immune Homeostasis, INSERM UMR1163, F-75015 Paris, France.ORCID 0000-0001-6671-3642

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) are professional antigen (Ag)-presenting cells that excel in initiating adaptive immune responses by continuously scanning peripheral tissues for Ags. To facilitate efficient DC migration, constant cross-talk between actin and microtubules is required to coordinate cytoskeletal networks and actomyosin contractility, but the related mechanisms have not been extensively characterized. We show that mouse DCs lacking Kif5b (the heavy chain of kinesin-1) exhibit a major impairment in cell migration in vivo and in vitro. Mechanistically, kinesin-1 coordinates cytoskeletal cross-talk between actin and microtubules during DC migration by modulating negatively RhoA activity through its interaction with GEF-H1, thereby limiting GEF-H1's availability in the cytosol. The same mechanism operates in human primary monocyte-derived DCs and regulates efficient migration in a confined environment. Thus, our results highlight kinesin-1 as a key regulator of DC migration, through its coordinated control of cytoskeletal dynamics.

Indexed as

Actin CytoskeletonCell MovementDendritic CellsKinesinsMicrotubulesAnimalsHumansMiceMice, KnockoutrhoA GTP-Binding ProteinRho Guanine Nucleotide Exchange FactorsKif5b protein, mouseKinesinsrhoA GTP-Binding ProteinRho Guanine Nucleotide Exchange Factors

Identifiers

PMID41105759
PMCPMC12533555

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.