Evidence map›Paper›PMID 41105511›Full record

ArticleCell reports2025

Long noncoding RNA-dependent control of Myc transcriptional bursting.

Qiao Li, Corinne Dilsavor, Valid Gahramanov, Erin Floyd, Jane Ding, J Justin Glynn, Ioannis Chiotakakos, Christiane E Olivero, Jesse R Zamudio, Nadya Dimitrova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qiao LiDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Corinne DilsavorDepartment of Molecular, Cell, and Developmental Biology, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Valid GahramanovDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Erin FloydDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Jane DingDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
J Justin GlynnDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Ioannis ChiotakakosDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Christiane E OliveroDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.
Jesse R ZamudioDepartment of Molecular, Cell, and Developmental Biology, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Nadya DimitrovaDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA. Electronic address: nadya.dimitrova@yale.edu.

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007499 · NIGMS · YALE UNIVERSITY · PI CARLSON, JOHN R, REINKE, VALERIE J · 1985 to 2022
$13.9M
Roles and mechanisms of cis-regulatory IncRNAs in the p53 tumor suppressor pathwayR37CA230580 · NCI · YALE UNIVERSITY · PI DIMITROVA, NADYA M · 2018 to 2024
$2.5M
Mechanisms of Genomic Stability by Mammalian Argonaute ProteinsR01GM143536 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZAMUDIO, JESSE R. · 2021 to 2024
$1.3M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
NCI NIH HHS P30 CA016359NCI NIH HHS R37 CA230580NIGMS NIH HHS R01 GM143536NIGMS NIH HHS T32 GM007499NIH HHS S10 OD030363
6 · The paper itself

Abstract

Genes are transcribed in short periods of activity, called bursts. Bursts are initiated by enhancer-promoter contacts and dynamically controlled by the levels of enhancer- and promoter-produced RNAs through a negative feedback mechanism. Here, by direct visualization of nascent transcripts, we show that chromatin-associated long noncoding RNAs (lncRNAs) contribute to the regulation of transcriptional bursting. We find that production of Pvt1 raises the baseline of RNA concentration in the locus of the Myc proto-oncogene and acts locally and in a dose-dependent manner to decrease the duration of Myc bursting. Premature termination of Pvt1 led to higher Myc expression and transcriptional activities, resulting in increased cellular proliferation and advanced tumor development in autochthonous models of lung cancer. These findings point to a critical lncRNA-mediated mechanism for Myc regulation and suggest a potentially widespread role for lncRNAs in fine-tuning gene expression through local control of transcriptional bursting.

Indexed as

Proto-Oncogene Proteins c-mycRNA, Long NoncodingTranscription, GeneticAnimalsCell Line, TumorCell ProliferationChromatinGene Expression Regulation, NeoplasticHumansLung NeoplasmsMicePromoter Regions, GeneticProto-Oncogene MasChromatinMAS1 protein, humanProto-Oncogene MasProto-Oncogene Proteins c-mycPVT1 long-non-coding RNA, humanRNA, Long NoncodingCP: Molecular biologylong noncoding RNAMycPvt1transcriptional burstingtumorigenesis

Identifiers

PMID41105511
PMCPMC12606467

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.