ArticleMolecular biology reports2025
Role of microRNA-761 in modulating laryngeal cancer cell proliferation, metastasis, and apoptosis: regulation of PDCD4 as a key mechanism.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
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5 authors.
Funding
Abstract
backgroundLaryngeal cancer is a leading global cause of cancer-related mortality. The regulatory interplay between dysregulated microRNA-761 (miR-761) and oncogenic signaling pathways in laryngeal carcinogenesis has not been fully elucidated.
methodsThis study explored the interaction between miR-761 and programmed cell death protein 4 (PDCD4) through dual-luciferase assay, cell proliferation and migration assays, and xenograft models.
resultsMiR-761 was significantly upregulated in laryngeal cancer tissues and cell lines, inversely correlating with PDCD4 downregulation. Computational predictions and dual-luciferase assays confirmed that miR-761 targets the 3'-UTR of PDCD4, inhibiting its transcription. Functional studies showed that miR-761 knockdown restored PDCD4 expression, increasing apoptosis and reducing proliferation and migration. Conversely, miR-761 overexpression enhanced these capacities in PDCD4-low cancer cells, effects reversed by PDCD4 upregulation. In vivo xenograft models demonstrated that miR-761 inhibition reduced tumor growth, with increased PDCD4 expression.
conclusionsMiR-761 is a critical regulator of PDCD4, modulating laryngeal cancer progression through apoptosis inhibition and pro-metastatic signaling. Targeting the miR-761/PDCD4 axis offers a promising therapeutic strategy for laryngeal cancer management.
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