ReviewJournal of materials science. Materials in medicine2025
Advances in hyaluronic acid-based biomaterials: applications in cancer therapy, wound healing, and disease management.
Review in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Polysaccharides and carbohydrate polymers: innovations from nature to industry.Journal of the science of food and agriculture · 2026Review
- Bridging Scales: Integrating Hyaluronan-Based Nanoencapsulation into 3D Hydrogel Constructs for Advanced Therapeutics-A Comprehensive Review.Gels (Basel, Switzerland) · 2026Review
- Biopolymer-Based Hydrogels for Wound Healing: Advances in Cellulose, Chitosan, Alginate, and Hyaluronic Acid from Design to Clinical Translation.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Hyaluronic Acid-Based Biomaterials for Soft Tissue Repair and Wound Healing: Clinical Evidence and Emerging Applications.Gels (Basel, Switzerland) · 2026Review
- Natural Polymers in Guided Bone Regeneration (GBR).Journal of functional biomaterials · 2026Review
- Sustainable Production of High-Performance Antimicrobial Scaffold via an EngineeredBiomolecules · 2026Article
- Glycosaminoglycans in tissue regeneration: Insights into glycobiology and their biomedical application.Bioactive materials · 2026Review
- Polymer-Based and Biomaterial Encapsulation of Probiotics for Improved Viability.Probiotics and antimicrobial proteins · 2026Review
- The Emerging Role of Hyaluronic Acid as a Multifunctional Regenerative Agent in Periodontal Healing.Gels (Basel, Switzerland) · 2026Review
- Hydrogel-Based Therapeutic Strategies for Post-Cholecystectomy NAFLD: Targeting Bile Acid Signaling, Gut Microbiota, Inflammation, and Hepatic Fibrosis.Gels (Basel, Switzerland) · 2026Review
- Clinical efficacy of intra-articular sodium hyaluronate injection and optimizing the puncture site in knee osteoarthritis.American journal of translational research · 2026Article
- Polysaccharide based biomaterials for advanced wound healing applications.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan and is essential in biomedical research due to its distinct properties, compatibility with biological tissues, and functions in preserving tissue hydration, lubrication, and the integrity of the extracellular matrix, a significance recognized since 1934. Its capability to develop hydrogels and react to environmental factors has provided it a strong factor for drug delivery, tissue engineering, and wound healing uses. This review emphasizes the various biomedical uses of HA-based materials, focusing on their functions in cancer treatment, wound healing, inflammation control, antibacterial properties, and antioxidant functions. In cancer treatment, HA-functionalized nanoparticles improve the targeted drug delivery by using the additional presence of CD44 receptors in cancer cells. HA-based hydrogels have demonstrated significant potential in advancing wound healing by regulating inflammatory responses, enhancing angiogenesis, and participating in the extracellular matrix remodeling. Moreover, HA's anti-inflammatory and antioxidant characteristics have been utilized in the treatment of chronic inflammatory conditions including osteoarthritis and inflammatory bowel disease. The recent developments in HA-based materials have also demonstrated their promise in antibacterial applications, diabetes control, and in treating cardiovascular and neurological conditions. The advancement of HA-based intelligent drug delivery systems and bioactive scaffolds is ongoing, presenting new treatment options for tissue repair and disease management. This review emphasizes the diverse functions of HA in both health and disease, showcasing its capacity to tackle various medical issues through cutting-edge biomedical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.