Evidence map›Paper›PMID 41105320›Full record

ArticleUpdates in surgery2026

The association between antiviral therapy and 10-year overall survival of patients undergoing liver resection for hepatitis C virus- or hepatitis B virus-related hepatocellular carcinoma.

Yi-Hao Yen, Yueh-Wei Liu, Chien-Hung Chen, Sheng-Nan Lu, Tsung-Hui Hu, Jing-Houng Wang, Chao-Hung Hung, Chee-Chien Yong, Wei-Feng Li, Chih-Chi Wang and 1 more

Abstract read
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In one paragraph

Article in Updates in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yi-Hao Yen *Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan. cassellyen@yahoo.com.tw.ORCID http://orcid.org/0000-0001-6251-7230
Yueh-Wei LiuLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Chien-Hung ChenDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan.
Sheng-Nan LuDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan.
Tsung-Hui HuDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan.
Jing-Houng WangDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan.
Chao-Hung HungDivision of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta Pei Road, Kaohsiung, Taiwan.
Chee-Chien YongLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Wei-Feng LiLiver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Chih-Chi Wang *Liver Transplantation Center and Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. ufel4996@ms26.hinet.net.
Chih-Yun LinBiostatistics Center of Kaohsiung Chang, Gung Memorial Hospital, Kaohsiung, Taiwan.

Funding

Kaohsiung Chang Gung Memorial Hospital CMRPG8L0181Kaohsiung Chang Gung Memorial Hospital CMRPG8L0182Kaohsiung Chang Gung Memorial Hospital CORPG8N0271
6 · The paper itself

Abstract

The efficacy of antiviral therapy against hepatitis C virus (HCV) and hepatitis B virus (HBV), following liver resection (LR) for hepatocellular carcinoma (HCC), has been studied extensively. However, its long-term overall survival (OS) benefit remains to be conclusively demonstrated. This retrospective cohort study included 1121 patients (777 with HBV-related HCC and 344 with HCV-related HCC) who underwent LR. The primary outcome was 10-year OS. The indication for antiviral therapy was serum HBV DNA > 2000 IU/ml in patients with HBV-related HCC and detectable serum HCV RNA in patients with HCV-related HCC. After propensity score matching, the 10-year OS of the antiviral-treated group was 58% and that of the untreated group was 25% (p < 0.001) in the HCV-infected cohort. The 10-year OS of the antiviral-treated group was 62% and that of the untreated group was 61% (p = 0.917) in the HBV-infected cohort. Antiviral therapy was associated with improved 10-year OS of patients with HCV-related HCC and viremia who underwent LR. In contrast, the 10-year OS of patients undergoing LR for HBV-related HCC who were treated with antiviral therapy based on serum HBV-DNA > 2000 IU/ml was similar to that of untreated patients.

Indexed as

Antiviral AgentsCarcinoma, HepatocellularHepatectomyHepatitis BHepatitis CLiver NeoplasmsAgedFemaleHepatitis B virusHumansMaleMiddle AgedRetrospective StudiesSurvival RateTime FactorsTreatment OutcomeAntiviral AgentsHepatitis B virusHepatitis C virusHepatocellular carcinomaLiver resectionOverall survival

Identifiers

PMID41105320

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.