Evidence map›Paper›PMID 41105315›Full record

Observational studyNeurosurgical review2025

Flow patterns inside the cerebral aneurysms affect aneurysm wall thickness.

Tatsuya Mori, Hidehito Kimura, Kosuke Hayashi, Yusuke Ikeuchi, Shunsuke Yamanishi, Hiroyasu Shose, Naoto Nakamura, Masahiro Sugihara, Akio Tomiyama, Eiji Kohmura and 1 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tatsuya MoriDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kusunoki-cho 7-5-1, Chuo-ku, Kobe, 〒650-0017, Japan.
Hidehito KimuraDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kusunoki-cho 7-5-1, Chuo-ku, Kobe, 〒650-0017, Japan. hkimura@med.kobe-u.ac.jp.
Kosuke HayashiGraduate School of Engineering, Kobe University, Kobe, Japan.
Yusuke IkeuchiDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kusunoki-cho 7-5-1, Chuo-ku, Kobe, 〒650-0017, Japan.
Shunsuke YamanishiDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kusunoki-cho 7-5-1, Chuo-ku, Kobe, 〒650-0017, Japan.
Hiroyasu ShoseDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kusunoki-cho 7-5-1, Chuo-ku, Kobe, 〒650-0017, Japan.
Naoto NakamuraDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kusunoki-cho 7-5-1, Chuo-ku, Kobe, 〒650-0017, Japan.
Masahiro SugiharaDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kusunoki-cho 7-5-1, Chuo-ku, Kobe, 〒650-0017, Japan.
Akio TomiyamaGraduate School of Engineering, Kobe University, Kobe, Japan.
Eiji KohmuraDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kusunoki-cho 7-5-1, Chuo-ku, Kobe, 〒650-0017, Japan.
Takashi SasayamaDepartment of Neurosurgery, Kobe University Graduate School of Medicine, Kusunoki-cho 7-5-1, Chuo-ku, Kobe, 〒650-0017, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The wall properties of cerebral aneurysms, whether thin or thick, cannot be determined using conventional imaging techniques. We previously reported that two parameters, wall shear stress vector direction variation (WSSDV) and oscillatory shear index (OSI), may predict the wall-thinning areas of cerebral aneurysm walls in computational fluid dynamics (CFD) analysis. In this study, we evaluated the positive predictive value (PPV) of these parameters in detecting thin-walled regions (TIWRs) and thick-walled regions (TKWRs) by performing preoperative CFD analysis and proposed that distinct flow patterns determine aneurysm wall thinning or thickening. A total of 42 microsurgical clipping surgeries for unruptured intracranial aneurysms (UIAs) were performed at our hospital between January 2019 and August 2022 without any deterioration of the modified Rankin scale in all patients. We identified 39 actual TIWRs (aTIWRs) in the intraoperative photographs of the aneurysms among 46 expected TIWRs (eTIWRs) of the color maps (PPV: 85%; 95% CI 0.72-0.92), 23 actual TKWRs (aTKWRs) among 29 expected TKWRs (eTKWRs, PPV: 79%; 95% CI 0.62-0.90) on the WSSDV color maps, whereas the OSI color map revealed 39 aTIWRs among 46 eTIWRs (PPV: 85%; 95% CI 0.72-0.92) and 30 aTKWRs among 45 eTKWRs (PPV: 67%; 95% CI, 0.52-0.79). Spearman's rank correlation analysis revealed a strong correlation between the WSSDV and OSI (Spearman's ρ = 0.849, 95% CI 0.73-0.92, p < 0.001). These two parameters reflected the degree of wall shear stress vector change during the cardiac cycle. Parallel or divergent flows may cause aneurysm wall thinning, whereas rotational or convergent flows may cause wall thickening.

Indexed as

Cerebrovascular CirculationIntracranial AneurysmAdultAgedFemaleHumansHydrodynamicsMaleMiddle AgedComputational fluid dynamicsIntracranial aneurysmOscillatory shear indexThick wallThin wallWall shear stress vector direction variation

Identifiers

PMID41105315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.