Evidence map›Paper›PMID 41105275›Full record

ArticleArchives of virology2025

Prevalence and genetic analysis of porcine circovirus type 3 (PCV3) in Henan Province of China during 2022-2024.

Lin-Lin Chen, Hao Li, Xuan-Ang Wang, Lan-Lan Zheng, Shi-Jie Ma, Hong-Ying Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lin-Lin Chen *The College of Veterinary Medicine, Henan Agricultural University, 218 Ping'an Avenue, Zhengdong New District, Zhengzhou, 450046, Henan, China.
Hao Li *The College of Veterinary Medicine, Henan Agricultural University, 218 Ping'an Avenue, Zhengdong New District, Zhengzhou, 450046, Henan, China.
Xuan-Ang Wang *The College of Veterinary Medicine, Henan Agricultural University, 218 Ping'an Avenue, Zhengdong New District, Zhengzhou, 450046, Henan, China.
Lan-Lan ZhengThe College of Veterinary Medicine, Henan Agricultural University, 218 Ping'an Avenue, Zhengdong New District, Zhengzhou, 450046, Henan, China.
Shi-Jie MaThe College of Veterinary Medicine, Henan Agricultural University, 218 Ping'an Avenue, Zhengdong New District, Zhengzhou, 450046, Henan, China. participate2006@126.com.
Hong-Ying ChenThe College of Veterinary Medicine, Henan Agricultural University, 218 Ping'an Avenue, Zhengdong New District, Zhengzhou, 450046, Henan, China. chhy927@163.com.ORCID http://orcid.org/0000-0002-8245-3999

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine circovirus 3 (PCV3) has emerged as a significant pathogen associated with various clinical manifestations affecting global swine populations. To investigate the prevalence and molecular characteristics of PCV3 strains, we collected 11,194 tissue samples from pigs across 650 farms of varying breeding scales in 18 cities of Henan province from March 2022 to December 2024. Detection of PCV3 was performed using a validated real-time quantitative PCR assay. The results showed that the total positive rate of PCV3 was 9.25% (1035/11,194), and PCV3 was detected on pig farms in 18 cities of Henan Province. The complete genome sequences of six PCV3 strains and the ORF2 gene sequences of four PCV3 strains were determined and analyzed. These 10 PCV3 strains shared 98% to 99.7% nucleotide sequence identity in ORF2 with PCV3 reference strains. The complete ORF2 gene sequences of these 10 PCV3 strains shared 98.4% to 99.8% nucleotide sequence identity with each other, and the encoded proteins shared 98.1% to 100% amino sequence acid identity. Phylogenetic analysis based on the ORF2 gene indicated that all 10 sequenced PCV3 strains belonged to genotype PCV3b. Notably, two amino acid mutations were identified in predicted B cell epitopes within the Cap protein of the these strains, which may affect the immunogenicity of PCV3. These data contribute to our understanding of the molecular epidemiology and evolution of PCV3 and provide a foundation for the prevention and control of PCV3 and other PCVs.

Indexed as

Circoviridae InfectionsCircovirusSwine DiseasesAnimalsChinaGenome, ViralGenotypeOpen Reading FramesPhylogenyPrevalenceSwine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.