ArticleMikrochimica acta2025
Electrochemical biosensor for CA125 detection based on ZIF-8@Au and TME-PTMC dual signal amplification.
Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cancer antigen 125 (CA125) is a key biomarker for ovarian cancer, and its concentration level is an important predictor for diagnosis. We developed a novel electrochemical impedance biosensor for CA125 detection based on a dual-signal amplification strategy using 1,1,1-tris(hydroxymethyl)ethane-polytrimethylene carbonate (TME-PTMC) and zeolitic imidazolate framework-8 loaded with gold nanoparticles (ZIF-8@Au). The biosensor was constructed by immobilizing ZIF-8@Au on a gold electrode using 1,6-hexanedithiol (HDT) as a crosslinking agent, followed by the attachment of aptamer 1 (Apt1) via sulfhydryl groups. 6-Mercapto-1-hexanol (MCH) was used to prevent nonspecific binding. Through specific aptamer-antigen recognition, CA125 was captured and anchored onto the electrode surface. After carbodiimide hydrochloride (EDC)/ N-hydroxysuccinimide (NHS) activation, aptamer 2 (Apt2) further recognized CA125, forming an aptamer-antigen-aptamer "sandwich structure". The TME-PTMC polymer was then conjugated via ester bonds, significantly enhancing signal amplification. Electrochemical impedance spectroscopy (EIS) analysis confirmed that under optimized conditions, the sensor exhibited a wide linear detection range (0.01 U mL
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