Evidence map›Paper›PMID 41105262›Full record

ArticleACS infectious diseases2025

Characterization of β-Carboline Derivatives Reveals a High Barrier to Resistance and Potent Activity against Ring-Stage and DHA-Induced Dormant

Reagan S Haney, Joshua H Butler, Lyric A Wardlaw, Emilio F Merino, Victoria Mendiola, Caitlin A Cooper, Jopaul Mathew, Patrick K Tumwebaze, Philip J Rosenthal, Roland A Cooper and 7 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Identification of an Orally Efficacious Imidazo[4,5-Journal of medicinal chemistry · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Reagan S HaneyDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-2452-4103
Joshua H ButlerDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.
Lyric A WardlawDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.
Emilio F MerinoDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-5400-7377
Victoria MendiolaCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, United States.
Caitlin A CooperCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, United States.
Jopaul MathewDepartment of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0002-4712-1403
Patrick K TumwebazeInfectious Diseases Research Collaboration, Kampala, Uganda.
Philip J RosenthalDepartment of Medicine, University of California, San Francisco, California 94110, United States.
Roland A CooperDepartment of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.
Dennis E KyleCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, United States.
Zaira RizopoulosMedicines for Malaria Venture, Geneva 1215, Switzerland.
Delphine BaudMedicines for Malaria Venture, Geneva 1215, Switzerland.ORCID 0009-0005-6745-233X
Stephen BrandMedicines for Malaria Venture, Geneva 1215, Switzerland.
Maxim TotrovMolSoft LLC, San Diego, California 92121, United States.ORCID 0000-0001-8594-274X
Paul R CarlierDepartment of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.ORCID 0000-0002-6683-285X
Maria Belen CasseraDepartment of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-6341-3169

Funding

Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
Optimization of antimalarials targeting multiple life stages of the parasiteR01AI157445 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Paul R Carlier, Maria Belen Cassera · 2021 to 2026
$4.5M
PREP at University of GeorgiaR25GM109435 · NIGMS · UNIVERSITY OF GEORGIA · PI DOLAN, ERIN L, KLONOWSKI, KIMBERLY D. · 2014 to 2024
$3.4M
NIAID NIH HHS R01 AI157445NIAID NIH HHS T32 AI060546NIGMS NIH HHS R25 GM109435
6 · The paper itself

Abstract

Malaria, caused by

Indexed as

AntimalarialsCarbolinesDrug ResistancePlasmodium falciparumAnimalsHumansMalaria, FalciparumMiceProtozoan ProteinsAntimalarialsCarbolinesProtozoan Proteinscollateral drug sensitivitydormancyirresistiblekelch-13malariaβ-carbolines

Identifiers

PMID41105262
PMCPMC12624827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.