Evidence map›Paper›PMID 41105224›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

The MIBI is dead, long live the MIBI: revisiting [99mTc]Tc-Sestamibi thyroid scintigraphy in the era of ultrasound, cytology, molecular diagnostic, and 18 F-FDG PET/CT.

Luca Giovanella, Alfredo Campennì, Luigi Mansi

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Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Luca GiovanellaDepartment of Nuclear Medicine and Thyroid Center, Gruppo Ospedaliero Moncucco, Clinica Moncucco, Via Soldino 10, Lugano, Switzerland.
Alfredo CampennìDepartment of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy. acampenni@unime.it.ORCID 0000-0002-0177-939X
Luigi MansiInteruniversity Research Center for Sustainability (CIRPS), Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

[99mTc]Tc-sestamibi (MIBI) thyroid scintigraphy has experienced fluctuating clinical relevance, overshadowed by the rise of ultrasound, cytology, molecular diagnostics, and FDG PET/CT. However, recent evidence highlights a reinvigorated role for MIBI in specific clinical niches, notably in indeterminate thyroid nodules and iodine-induced thyroid dysfunctions. Our opinion paper synthetizes the biological background of thyroid imaging with MIBI, including semi-quantitative analysis. Current clinical indications and clinical results are discussed taking into account the emerging role of 18 F-FDG PET/CT in the field of cytologically indeterminate thyroid nodules offering a balanced perspective on integrating MIBI into modern thyroid diagnostics.

Indexed as

Fluorodeoxyglucose F18Molecular Diagnostic TechniquesPositron Emission Tomography Computed TomographyTechnetium Tc 99m SestamibiThyroid GlandHumansPathology, MolecularRadionuclide ImagingRadiopharmaceuticalsThyroid NoduleUltrasonographyFluorodeoxyglucose F18RadiopharmaceuticalsTechnetium Tc 99m SestamibiFDG nodulesIodineSestaMIBIThyroidThyrotoxicosisWash-out index

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.