Evidence map›Paper›PMID 41105032›Full record

ArticleCritical care explorations2025

Impact of ICU Length of Stay and Illness Severity on Rehabilitation Progress and Functional Recovery: A Secondary Analysis of the Japanese Rehabilitation and Risk Factors on the Post-Intensive Care Syndrome (J-RELIFE) Prospective Registry.

Yorihide Yanagita, Yuki Iida, Shinichi Watanabe, Tomoyuki Morisawa, Yusuke Kawai, Ryo Kozu, Shigeaki Inoue, Japanese Rehabilitation and Risk Factors on the Post-Intensive Care Syndrome (J-RELIFE) Study Group Collaborators

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yorihide YanagitaDepartment of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.ORCID 0000-0002-5800-3736
Yuki IidaMajor of Physical Therapy Sciences, Department of Medical Sciences, Faculty of Health and Medical Sciences, Aichi Shukutoku University, Aichi, Japan.
Shinichi WatanabeDepartment of Physical Therapy, Faculty of Rehabilitation, Gifu University of Health Science, Gifu, Japan.
Tomoyuki MorisawaDepartment of Rehabilitation, Kobe Rehabilitation Hospital, Kobe, Japan.
Yusuke KawaiDepartment of Nursing, Fujita Health University Hospital, Toyoake, Japan.
Ryo KozuDepartment of Physical Therapy Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Shigeaki InoueDepartment of Emergency and Critical Care Medicine, Wakayama Medical University, Wakayama, Japan.
Japanese Rehabilitation and Risk Factors on the Post-Intensive Care Syndrome (J-RELIFE) Study Group Collaborators

Funding

the Nagasaki University Fund for Domestic and Overseas Research Support, 2025 none
6 · The paper itself

Abstract

importanceAlthough survival rates in ICUs have improved, ICU length of stay is increasing, particularly among critically ill patients requiring prolonged mechanical ventilation. These patients often face challenges in early rehabilitation. Despite the importance of early mobilization, its implementation is often hindered by the severity of patient conditions. The details of rehabilitation interventions, particularly the element of intervention time, have not been fully examined.

objectivesThis study evaluated the time, content, and effects of rehabilitation during ICU stays. DESIGN, SETTING, AND

participantsThis study is a secondary analysis of data from the Japanese Rehabilitation and Risk Factors on the Post-Intensive Care Syndrome (J-RELIFE) prospective multicenter registry, which enrolled critically ill patients across 22 institutions in Japan. From this registry, we identified 423 patients who underwent mechanical ventilation in the ICU for greater than 48 hours. Patients were categorized into three groups based on ICU stay length: short-, medium-, and long-term (199, 157, and 67 patients, respectively). MAIN OUTCOMES AND MEASURES: The primary variable was rehabilitation intervention time in the ICU, analyzed relative to ICU stay length. Secondary measures included the association between rehabilitation time and the highest Sequential Organ Failure Assessment (SOFA) score, as well as functional outcomes at ICU and hospital discharge.

resultsThe long-term group had significantly greater rehabilitation time (p < 0.05). A significant correlation was observed between rehabilitation time and highest SOFA score (r = 0.354; p < 0.001). In the long-term ICU group, even with high illness severity and delayed mobilization, patients' activities of daily living were restored by discharge. CONCLUSIONS AND RELEVANCE: Our registry-based analysis shows that severely ill ICU patients require extended rehabilitation interventions. This highlights the need for staffing and implementation systems that can ensure sufficient rehabilitation time for severely ill patients.

Indexed as

Critical IllnessIntensive Care UnitsLength of StayRecovery of FunctionAgedCritical CareEast Asian PeopleFemaleHumansJapanMaleMiddle AgedProspective StudiesRegistriesRespiration, ArtificialRisk Factorsillness severityintensive care unitpost-intensive care syndromerehabilitation timeSequential Organ Failure Assessment

Identifiers

PMID41105032
PMCPMC12537117

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.