ArticleInternational journal of molecular medicine2025
RP105 exerts hepatoprotective effects in sepsis by modulating the SOCS2/JAK2/STAT3 signaling pathway.
Article in International journal of molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Maresin-1 Alleviates Sepsis-Induced Liver Injury by Regulating Apoptosis and Autophagy via Activation of the PI3K/Akt Signaling Pathway in Mice.Current issues in molecular biology · 2026Article
- SIRT6 Aggravates Psoriasiform Skin Inflammation Through Modulation of the SOCS2-STAT1/3 Pathway.Journal of inflammation research · 2026Article
- Macrophage polarization in ischemia-reperfusion injury: from molecular mechanisms to therapeutic strategies.Frontiers in immunology · 2026Review
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Authors and funding
8 authors.
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Abstract
Sepsis‑induced liver injury increases mortality through inflammatory dysregulation. Although Radioprotective 105 (RP105) modulates inflammation, its role in septic liver injury remains unclear. The present study investigates the mechanism of RP105 in sepsis‑driven hepatic damage. Sepsis was induced in RP105 knockout (KO) and wild‑type (WT) mice via cecal ligation and puncture (CLP). Liver injury was assessed by serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST), histology (H&E), inflammatory markers (anti‑myeloperoxidase, F4/80, IL‑1β, IL‑6 and TNF‑α) and apoptosis markers (Caspase‑3, BAX/BCL‑2 ratio, GADD45A and PUMA). RNA sequencing identified key differentially expressed genes. RP105‑suppressor of cytokine signaling (SOCS) 2 interaction was validated by co‑immunoprecipitation (Co‑IP) and JAK2/STAT3 pathway activity was measured by western blotting. Lipopolysaccharide‑stimulated RP105‑KO macrophages were used
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