Evidence map›Paper›PMID 41104617›Full record

ArticleMicrobiologyOpen2025

The Road Less Traveled: Exploring the Genomic Characteristics and Antimicrobial Resistance Potential of Acinetobacter baumannii From the Indigenous Orang Asli Community in Peninsular Malaysia.

Soo-Sum Lean, Denise E Morris, Rebecca Anderson, Ahmed Ghazi Alattraqchi, David W Cleary, Stuart C Clarke, Chew Chieng Yeo

Abstract read
In one paragraph

Article in MicrobiologyOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Soo-Sum LeanFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.ORCID 0000-0002-2239-2004
Denise E MorrisFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.ORCID 0000-0002-8920-0812
Rebecca AndersonFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.
Ahmed Ghazi AlattraqchiCentre for Research in Infectious Diseases and Biotechnology, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, Malaysia.
David W ClearyDepartment of Microbes, Infections and Microbiomes, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.ORCID 0000-0003-4533-0700
Stuart C ClarkeFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.ORCID 0000-0002-7009-1548
Chew Chieng YeoCentre for Research in Infectious Diseases and Biotechnology, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, Malaysia.ORCID 0000-0002-9644-6925

Funding

This study was funded by a Newton Fund Institutional Links award to S.C.C. (Grant No. 172686537), and two University of Southampton HEFCE Newton Fund Official Development Assistance (ODA) awards, one each to S.C.C. and D.W.C. D.W.C. was also supported by the National Institute for Health Research through the NIHR Southampton Biomedical Research Centre.
6 · The paper itself

Abstract

Acinetobacter baumannii is widely recognized as a multidrug-resistant pathogen, although most public genome datasets are biased toward hospital-derived isolates. Little is known about A. baumannii isolates from healthy individuals in the community. This study analyzed genome sequences from nine A. baumannii isolates obtained from the upper respiratory tract of the indigenous Orang Asli in their rural community in Peninsular Malaysia. Genomic analysis revealed genetic diversity, including three new Pasteur sequence types (STs) and six novel Oxford STs. One isolate, A. baumannii 19064, belonged to Global Clone 8 (GC8), a lineage linked to clinical infections. Core genome phylogeny showed these community isolates interspersed with clinical isolates from a nearby hospital, indicating potential pathogenicity under suitable conditions. All isolates carried intrinsic bla

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsDrug Resistance, Multiple, BacterialAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesGenetic VariationGenome, BacterialHumansMalaysiaMicrobial Sensitivity TestsPhylogenyPlasmidsAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasescarbapenemaseantibiotic resistance genesindigenous community Acinetobacter baumanniiOrang Aslipdif modulesplasmidsvirulence factors

Identifiers

PMID41104617
PMCPMC12531904

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.