Evidence map›Paper›PMID 41104604›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Carotid and regional arterial stiffness and dementia-related imaging biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA).

Sheina Emrani, Jordan Tanley, Christopher L Schaich, Sanjiv Shah, Alain G Bertoni, Claudia Korcarz, Susan R Heckbert, Mohamad Habes, Samuel N Lockhart, Julio A Chirinos and 9 more

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sheina EmraniDepartment of Neurology, Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1235-5285
Jordan TanleyDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Christopher L SchaichDepartment of Surgery, Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Sanjiv ShahDepartment of Cardiology, Northwestern University School of Medicine, Chicago, Illinois, USA.
Alain G BertoniDivision of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Claudia KorcarzCardiovascular Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Susan R HeckbertDepartment of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA.
Mohamad HabesNeuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA.
Samuel N LockhartDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Julio A ChirinosDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jingzhong DingDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
James H SteinCardiovascular Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Adam D GepnerCardiovascular Division, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
R Nick BryanDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ilya M NasrallahDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
José A LuchsingerDepartments of Medicine and Epidemiology, Columbia University Irving Medical Center, New York, New York, USA.
Kathleen M HaydenDepartment of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Yongmei LiuDepartment of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, USA.
Timothy M HughesDepartment of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

Funding

Subclinical Vascular Contributions to Alzheimer's Disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Multisite Study of AD (Renewal)R01AG058969 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Timothy M. Hughes, YONGMEI LIU · 2018 to 2026
$33.4M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Sharon Letchworth · 2021 to 2026
$24.3M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Atrial fibrillation burden, vascular disease of the brain and cardiac MRI in MESAR01HL127659 · NHLBI · UNIVERSITY OF WASHINGTON · PI HECKBERT, SUSAN R · 2015 to 2018
$7.4M
A Longitudinal Epigenetic Study of AtherosclerosisR01HL135009 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LIU, YONGMEI · 2017 to 2020
$5.8M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
TO EXERCISE OPTION PERIOD ONE (1) FOR TASK AREA A - MESA CORE OPERATIONS, FIELD CENTER.75N92020D00004 · NHLBI · NORTHWESTERN UNIVERSITY · PI SIEGEL, JONATHAN H · 2020 to 2025
$4.5M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00006 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANKOW, JAMES S · 2020 to 2025
$4.4M
Cell-specific genomic features of Alzheimer's disease progressionRF1AG054474 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DING, JINGZHONG, LIU, YONGMEI · 2017 to 2019
$4.1M
The Macrovascular and Microvascular Contributions to Alzheimer's Disease: MESA VASCADR01AG054069 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M. · 2016 to 2020
$3.8M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00003 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY S · 2020 to 2025
$3.8M
Epigenome-Wide Association Study of DNA Methylation and AtherosclerosisR01HL101250 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LIU, YONGMEI · 2009 to 2013
$3.6M
NCATS NIH HHS R01AG054069NCATS NIH HHS R01AG058969NCATS NIH HHS R01AG080048NCATS NIH HHS RF1AG054474NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS R01 HL101250NHLBI NIH HHS R01 HL126477NHLBI NIH HHS R01 HL127659NHLBI NIH HHS R01 HL135009NHLBI NIH HHS UL1-TR-000040NHLBI NIH HHS UL1-TR-001079NHLBI NIH HHS UL1-TR-001420NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG054069NIA NIH HHS R01 AG058969NIA NIH HHS R01 AG068629NIA NIH HHS R01 AG080048NIA NIH HHS R01HL101250NIA NIH HHS R01HL126477NIA NIH HHS R01HL127659NIA NIH HHS R01HL135009NIA NIH HHS R03 AG064569NIA NIH HHS RF1 AG054474
6 · The paper itself

Abstract

introductionArterial stiffness measured within various arterial beds may be differentially associated with neuroimaging biomarkers of dementia.

methodsWe related carotid and regional (cardio-ankle vascular index [CAVI] and heart-ankle pulse wave velocity [haPWV]) arterial stiffness measures to biomarkers (gray matter volume [GMV], white matter hyperintensity volume [WMHV], and fractional anisotropy [WMFA]) and amyloid positron emission tomography (PET) positivity (centiloid > 12.2), controlling for covariates.

resultsAll arterial stiffness measures were associated with higher WMHV. Lower carotid distensibility (increased mechanical stress) was positively associated with WMFA, while Young's elastic modulus and haPWV (greater stiffness) were associated with lower WMFA. Only CAVI was significantly related to amyloid PET positivity, although similar effect sizes were observed for carotid measures. No main associations were observed with GMV. Significant interactions showed men and Black and Hispanic participants had stronger associations between carotid stiffness and GMV.

conclusionsCarotid stiffness measures were associated with WM injury while regional CAVI measures were associated with amyloid positivity. HIGHLIGHTS: We studied differences between carotid ultrasound and regional (cardio-ankle vascular index [CAVI] and heart-ankle pulse wave velocity [haPWV]) measures of arterial stiffness and neuroimaging abnormalities (white matter changes and amyloid positron emission tomography [PET] positivity) in the Multi-Ethnic Study of Atherosclerosis, a diverse cohort of older adults. Carotid measures were associated with white matter injury, demonstrated usingwhite matter hyperintensity volume and white matter fractional anisotropy, and were not associated with amyloid PET positivity. Regional measures had variable relationships with white matter injury and CAVI, and in particular, were associated with amyloid deposition. Black and Hispanic participants had significant associations between arterial stiffness measures and brain volume that were not observed in White participants. Men showed significant associations with carotid distensibility and white matter injury while women did not.

Indexed as

AtherosclerosisCarotid ArteriesDementiaVascular StiffnessAgedAged, 80 and overBiomarkersCardio Ankle Vascular IndexEthnicityFemaleHumansMagnetic Resonance ImagingMalePositron-Emission TomographyPulse Wave AnalysisWhite MatterBiomarkersamyloid beta depositionarterial stiffnesscerebrovascular diseaseneuroimaging

Identifiers

PMID41104604
PMCPMC12531903

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