Evidence map›Paper›PMID 41104495›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2025

Case series of Oropouche fever among travellers returning from Cuba to Spain, 2024.

Nuria Labiod, Mª Paz Sánchez-Seco, Josune Goikoetxea, Nelly Daniela Zurita, Francesca F Norman, Miguel M Martínez, Pedro Alonso Alonso, Araceli Hernández-Betancor, Marco Antonio Sempere-Alcocer, Zaira Moure and 14 more

Abstract readCase Reports
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Nuria LabiodArboviruses and Viral Imported Diseases Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.
Mª Paz Sánchez-SecoArboviruses and Viral Imported Diseases Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.
Josune GoikoetxeaInfectious Diseases Department, Hospital Universitario de Cruces, Instituto de investigación sanitaria Biobizkaia, Spain.
Nelly Daniela ZuritaServicio de Microbiología del Hospital Universitario de La Princesa, Madrid, Spain.
Francesca F NormanCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain.
Miguel M MartínezCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain.
Pedro Alonso AlonsoServicio Microbiología, Hospital Monforte de Lemos, Lugo, Spain.
Araceli Hernández-BetancorServicio de Microbiología, Hospital Universitario Insular de Gran Canaria (HUIGC), Las Palmas, Spain.
Marco Antonio Sempere-AlcocerClinical Microbiology Department. Hospital Universitario Virgen de la Victoria, Málaga, Spain.
Zaira MoureClinical Microbiology Department, Hospital Universitario Marqués de Valdecilla, Instituto de investigación sanitaria Valdecilla (IDIVAL), Santander, Spain.
Maria Dolores OceteMicrobiology Department, Hospital General Universitario de Valencia, Valencia, Spain.
Maria Rosario VicenteSección de Enfermedades Infecciosas. Hospital General Universitario Reina Sofia. Murcia, Spain.
Fernando de la Calle-PrietoCentro de Referencia Nacional para Patología Importada y Salud Internacional, Adultos y Pediatría, Hospital La Paz-Carlos III, Madrid, Spain.
Mikel GallegoClinical Microbiology Department, Hospital Universitario de Cruces, Instituto de Investigación Sanitaria Biobizkaia, Barakaldo, Spain.
Laura Cardeñoso DomingoServicio de Microbiología del Hospital Universitario de La Princesa, Madrid, Spain.
Juan Carlos GalánCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Daniel Camprubí-FerrerInternational Health Department, Hospital Clínic de Barcelona, Barcelona, Spain.
Carlos MeilánEmergency Department, Hospital Monforte de Lemos, Lugo, Spain.
Isabel Perez-HernandezUnidad de Enfermedades Infecciosas. Hospital Universitario Virgen de la Victoria, Málaga, Spain.
Itxasne CabezónInfectious Diseases Department, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Santander, Spain.
Francisco Javier HernándezMicrobiology Department, Hospital General Universitario de Valencia, Valencia, Spain.
Enrique BernalInstituto Murciano de Investigación Biosanitaria (IMIB), Universidad de Murcia, Murcia, Spain.
Ana VázquezArboviruses and Viral Imported Diseases Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.
Spanish-OROV Study GroupThe members of the Spanish OROV Study Group are listed under Acknowledgements.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oropouche fever is a vector-borne disease endemic in Central and South America. Infection with Oropouche virus (OROV) was confirmed in June and July 2024 in 13 patients travelling from Cuba to Spain. These patients presented fever, headache, myalgia and arthralgia, and three patients exhibited a biphasic course, with two developing transient neurological symptoms. Oropouche virus infection was diagnosed using reverse transcription quantitative PCR (RT-qPCR) and neutralisation tests. Viral RNA was detected in specimens from serum, urine, plasma and whole blood; from four urine samples up to 24 days post-symptom onset. Phylogenetic analysis of one OROV strain (OROV SP2024) isolated from one patient, demonstrated it clustered closely with reassortant strains circulating in Brazil and imported cases in Italy. These findings underscore the importance of including OROV in the differential diagnosis of febrile illnesses in returning travellers and demonstrate the diagnostic value of analysing multiple sample types. Enhanced clinical awareness and diagnostic capacity are essential to improve detection and surveillance of OROV among international travellers from affected regions.

Indexed as

Bunyaviridae InfectionsOrthobunyavirusTravelCubaFeverHeadacheHumansMyalgiaPhylogenyReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, ViralSpainRNA, ViralarbovirusdiagnosisEmergenceEpidemiological SurveillanceImported casesOropouche virus

Identifiers

PMID41104495
PMCPMC12534779

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.