ArticleJournal of oral biology and craniofacial research
Curcumin mitigates the histopathological and molecular changes in sublingual glands in diabetic male rats.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: demonstrate the possible palliative role of curcumin in the prospective molecular and histological alterations in the sublingual glands of diabetic male rats. Methods: Twenty-one male adult rats were used and randomly assigned into three groups (n = 7). The control group consisted of rats administered a single IP injection of saline. The diabetic group included rats receiving one dose of alloxan (140 mg/kg). The nanocurcumin-treated rat group (NC group) contained diabetic rats administered 200 mg/kg nanocurcumin. After 42 days, the salivary glands were dissected and assessed for Masson trichrome, Hematoxylin and eosin (H&E) staining, expression of c-kit and β-catenin, and histomorphometric analysis. Results: The sublingual glands of diabetic rats revealed altered histology. In addition, the salivary tissues depicted an apparent change in β-catenin, and c-kit expression. The NC group resumed the normal sublingual gland architecture and c-kit and β-catenin expression. Conclusion: Curcumin treatment rescued the histological and molecular changes in the sublingual glands of the diabetic rats. The ameliorating effect of curcumin on sublingual tissues of diabetic rats may be due to resuming of expression of β-catenin suggesting restoration of Wnt/β-catenin signaling in the glandular tissues which can maintain the c-kit + glandular stem/progenitor cells.
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