Evidence map›Paper›PMID 41104340›Full record

ReviewFrontiers in pharmacology2025

Pharmacogenomics of antibiotic-induced hypersensitivity reactions: current evidence and implications in clinical practice.

Mohitosh Biswas, Murshadul Alam Murad, Md Ismail Hossain Ashik, Maliheh Ershadian, Chonlaphat Sukasem

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohitosh Biswas *Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, Bangladesh.
Murshadul Alam Murad *Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, Bangladesh.
Md Ismail Hossain AshikDepartment of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, Bangladesh.
Maliheh ErshadianDivision of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Chonlaphat SukasemDivision of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adverse drug reactions (ADRs) are gradually becoming a concerning health threat worldwide in patients undergoing acute or chronic therapy. Antibiotics are the main drugs that cause immune-mediated ADRs, such as severe cutaneous adverse reactions (SCARs), allergic reactions, and organ-specific diseases, representing a significant threat to patient safety. In this review, we present the current genetic evidence available for antibiotic-related toxicities from a pharmacogenomics (PGx) perspective. We also explore the current state of PGx-based dosing recommendations and the factors limiting their widespread application in routine clinical practice. Through a systematic literature review, this study identified at least 12 antibiotic-gene pairs (amikacin-

Indexed as

antibioticshypersensitivityliver injurypharmacogenomicsprecision medicinesevere cutaneous adverse drug reactions

Identifiers

PMID41104340
PMCPMC12521184

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.