Evidence map›Paper›PMID 41104290›Full record

ArticleFrontiers in human neuroscience2025

Hormonal contraceptive use is associated with reduced central serotonergic activity indexed by the loudness dependence of auditory evoked potentials.

Henrik Normannseth, Christoffer Hatlestad-Hall, Trine Waage Rygvold, Alena Hadzic, Stein Andersson

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In one paragraph

Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Henrik NormannsethSection for Clinical and Cognitive Neuroscience, Department of Psychology, University of Oslo, Oslo, Norway.
Christoffer Hatlestad-HallDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Trine Waage RygvoldDepartment of Clinical Neurosciences for Children, Oslo University Hospital, Oslo, Norway.
Alena HadzicSection for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway.
Stein AnderssonSection for Clinical and Cognitive Neuroscience, Department of Psychology, University of Oslo, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Hormonal contraceptives (HCs) are linked to mood disturbances, but the neurobiological mechanisms remain unclear. This study investigated whether HC use is associated with altered central serotonergic activity, using the loudness dependence of auditory evoked potentials (LDAEP). Methods: Fifty-four healthy women (30 current HC users and 24 non-users) completed EEG recordings to assess LDAEP. Depressive symptoms were quantified using the Beck Depression Inventory-II. Between-group analyses were controlled for age and depressive symptoms, and effects of menstrual cycle phase, HC type, and mood-related side effects were also examined. Results: HC users showed significantly steeper LDAEP slopes than non-users across components (all Conclusion: This study is, to our knowledge, among the first to explicitly test an

Indexed as

central serotonergic activitydepressive symptomshormonal contraceptivesloudness dependence of auditory evoked potential (LDAEP)sex hormones

Identifiers

PMID41104290
PMCPMC12521447

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.