ArticleIranian journal of pharmaceutical research : IJPR
The Impact of Black Walnut (
Article in Iranian journal of pharmaceutical research : IJPR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hypothyroidism is a major endocrine disorder characterized by the dysfunction of thyroid hormones. Objectives: This study aimed to investigate the potential therapeutic effects of an oily extract derived from black walnut ( Methods: In this experimental study, hypothyroidism was induced by the oral administration of methimazole at a single dose of 25 mg/kg body weight. In this research, 40 adult male rats were used in five groups of eight, all of which were administered orally. At the end of the experimental period, blood samples were collected from the hearts of animals for the evaluation of oxidative stress and thyroid function parameters. Serum malondialdehyde (MDA) and nitric oxide (NO) levels were assessed as markers of oxidative stress, while catalase (CAT) and superoxide dismutase (SOD) enzyme activities were measured as indicators of antioxidant defense. Thyroid hormone levels [triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH)] were determined using ELISA-based assay kits. Statistical analysis was performed using one-way ANOVA followed by Tukey's post-hoc test. Results: Black walnut kernel oil was found to contain essential fatty acids, various hydrocarbons, and phenolic compounds. Consequently, using treatment with black walnut kernel extract in hypothyroidism rats, the SOD and T4 levels were decreased in the methimazole-treated stress group in comparison with the control group (P > 0.05), while T3 and CAT levels were significantly decreased in the methimazole-treated stress group in comparison with the control group (P < 0.05). Furthermore, the TSH, Anti thyroid peroxidase (TPO), NO, and MDA levels were increased in the methimazole-treated stress group in comparison with the control group (P > 0.05). Conclusions: Although the ethanolic extract of black walnut (
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