ArticleIranian journal of pharmaceutical research : IJPR
Anti-proliferative Activity and Apoptosis Induction of Extracts and Fractions of
Article in Iranian journal of pharmaceutical research : IJPR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Anticancer Activity of Miswak Root Extract in Breast Cancer Cell Line: HRLC-MS/MS Profiling, In Vitro Evaluation, and In Silico Analysis.International journal of molecular sciences · 2026Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: At present, regarding the optimal potential for prevention and treatment of cancer, medicinal plants have received more attention than before. Methods: In the present study, different extracts of Results: The chloroform and ethyl acetate extracts provided the highest toxicity against A2780 and were fractioned into A-E and F-J, respectively. Fractions C and F resulted in reducing the mitochondrial membrane potential (MMP), while fractions C, E, F, and I led to an increase in the activity of the caspase-3 enzyme. Fractions B, C, and I increased the reactive oxygen species (ROS) in the A2780 cells. Conclusions: Considering the reduction in MMP and the increase in caspase-9 by fraction C, it can be said that apoptosis is induced by the intrinsic pathway.
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