ArticleIranian journal of pharmaceutical research : IJPR
Anti-tumor Effects of
Article in Iranian journal of pharmaceutical research : IJPR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Immune and Tumor Microenvironment Mechanisms ofCancers · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cervical cancer is among the most prevalent malignancies affecting women globally. This study examines the anti-tumor effects and mechanisms of Methods: The effects of HDW on the proliferation and migration of SiHa and CaSki cells were evaluated through in vitro assays. Additionally, the anti-tumor activity of HDW was assessed in vivo using a xenograft mouse model. To further explore its potential mechanisms, the effects of HDW on apoptosis, the cell cycle, and the IL-17/NF-κB signaling pathway were analyzed. Results: In vitro, HDW dose-dependently reduced the proliferation, colony formation, and migration of SiHa and CaSki cervical cancer cells (P < 0.01). It induced apoptosis by modulating the expression of BCL2, BAX, caspase 3, and cleaved-caspase 3, and caused S-phase cell cycle arrest through suppression of CDK2 and cyclin A (P < 0.05 or P < 0.01). Conclusions: These findings suggest that HDW exerts its anti-tumor effects by inducing apoptosis, causing cell cycle arrest, and inhibiting the IL-17/NF-κB signaling pathway, highlighting its potential as a promising therapeutic candidate for cervical cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.