ArticleIranian journal of pharmaceutical research : IJPR
Enhanced Hyaluronic Acid Production in
Article in Iranian journal of pharmaceutical research : IJPR. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Optimization of hyaluronic acid production through co-culture of mutant Streptococcus zooepidemicus and Streptococcus pyogenes under controlled uv and environmental conditions.Bioprocess and biosystems engineering · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Objectives: This study focuses on strain optimization and the purification of HA. The key goals include reducing hyaluronidase activity, which degrades HA, eliminating beta-hemolytic traits, and developing a purification process that significantly minimizes organic solvent consumption to lower costs and reduce environmental impact. Methods: UV-induced physical mutagenesis and chemical mutagenesis utilizing nitrous acid and N-methyl-N'-nitro-N-nitrosoguanidine (NTG) were employed to generate mutant strains with diminished hyaluronidase activity and beta-hemolytic properties. Following strain optimization, an efficient downstream process was implemented, focusing on pre-treatment methods involving pH and temperature adjustments, followed by ultrafiltration and phenol acetate treatment. Results: The selected mutant, designated as Conclusions: The study presents an integrated approach to HA production, encompassing strain improvement and purification. It addresses key challenges in the manufacturing of streptococcal HA and contributes to the development of more efficient and environmentally friendly purification methods, ultimately resulting in high-purity HA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.