ArticleJournal of human reproductive sciences
Investigating the Impact of
Article in Journal of human reproductive sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypothalamic pituitary gonadal axis plays a pivotal role in reproductive physiology, and gonadotropin-releasing hormone 1 (GNRH1) is considered to be the candidate gene in the regulation of the hypothalamic-pituitary-gonadal axis. GNRH1 encodes the pre-proprotein that is processed proteolytically to form the peptide GnRH1. Its polymorphisms may involve in the disruption of the luteinising hormone/follicle-stimulating hormone (LH/FSH) ratio and cause polycystic ovary syndrome (PCOS). Aim: The current study investigated the genetic association of rs6185 with PCOS. In addition, Settings and Design: A total of 362 PCOS women and 328 healthy controls were analysed in a case control design. Materials and Methods: GNRH1 polymorphism rs6185 was genotyped using the ARMS-PCR method. Lipid and hormonal profiles were measured to analyse the correlation between genotype and phenotype. Statistical Analysis Used: The Chi-square test compared genotypic and allelic frequencies between cases and controls, and the effect was estimated by calculating the Odds ratios at a 95% confidence interval. For meta-analysis, Review Manager 5.4.1 software was used. Results: In the present study, body mass index, waist-to-hip ratio, cholesterol, triglycerides, low-density lipoprotein (LDL), very LDL, LH and LH/FSH ratio were found to be higher in PCOS women. The significant difference in the distribution of the homozygous mutant genotype (GG) and mutant allele (G) of rs6185 was found between PCOS cases and controls ( Conclusion: The present study demonstrates that there is a significant association of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.