ArticleJournal of human reproductive sciences
Angiotensin-converting Enzyme Insertion/Deletion Polymorphism Distribution in the North Indian Population of Jammu and Kashmir and Its Positive Correlation with Male Infertility: A Case Control Study.
Article in Journal of human reproductive sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background: A precise balance among angiotensin-converting enzyme (ACE), angiotensin-II (Ang-II) and Ang-II type 1 receptor is essential for spermatogenesis. Any alteration in this balance can potentially lead to infertility. Aim: To study the potential association of the Settings and Design: This case-control genetic association study was conducted on 362 subjects in the North Indian population of Jammu and Kashmir. All participants provided informed consent, and the study was approved by the institutional human ethics committee. Materials and Methods: DNA was extracted from blood using a kit (Qiagen Pvt. Ltd., Germany). The primer sequence was taken from the literature. Ready-to-use PCR mix from Takara Bioscience was used to genotype the Statistical Analysis Used: Logistic regression, Results: The D allele frequency in combined cases was significantly higher than in the control group, with values of 0.52 compared to 0.34 ( Conclusion: Our study is the first report linking the
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