Evidence map›Paper›PMID 41104176›Full record

ArticleFrontiers in surgery2025

Multimodal therapeutic options for esophageal perforations-a single-center experience.

Maximilian Gruber, Lars Kollmann, Johan Friso Lock, Sven Flemming, Stanislaus Reimer, Markus Brand, Armin Wiegering, Alexander Meining, Ivan Aleksic, Christoph-Thomas Germer and 1 more

Abstract read
In one paragraph

Article in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maximilian GruberDepartment of General-, Visceral-, Transplantation-, Vascular-, and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Lars KollmannDepartment of General-, Visceral-, Transplantation-, Vascular-, and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Johan Friso LockDepartment of General-, Visceral-, Transplantation-, Vascular-, and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Sven FlemmingDepartment of General-, Visceral-, Transplantation-, Vascular-, and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Stanislaus ReimerDepartment of Gastroenterology, Caritas Hospital, Bad Mergentheim, Germany.
Markus BrandDepartment of Gastroenterology, University Hospital Wuerzburg, Wuerzburg, Germany.
Armin WiegeringDepartment of General, Visceral, Transplant, and Thoracic Surgery, University Hospital of Frankfurt, Frankfurt, Germany.
Alexander MeiningDepartment of Gastroenterology, University Hospital Wuerzburg, Wuerzburg, Germany.
Ivan AleksicDepartment of Thoracic and Cardiovascular Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Christoph-Thomas GermerDepartment of General-, Visceral-, Transplantation-, Vascular-, and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.
Florian SeyfriedDepartment of General-, Visceral-, Transplantation-, Vascular-, and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Esophageal perforation is a life-threatening condition with a high mortality rate. The current therapeutic options range from conservative to endoscopic to surgical treatment. We aimed to compare specific patterns of multimodal management of spontaneous vs. other esophageal perforations. Methods: The data from all consecutive patients diagnosed with either spontaneous (Boerhaave syndrome, BS) vs. other esophageal perforation (OEP) between 2010 and 2023 were prospectively collected and retrospectively analyzed. The primary endpoint was in-hospital mortality. The secondary endpoints were overall complications (Comprehensive Complication Index, CCI), therapy-associated complications, oral nutrition at discharge, and length-of-stay. Results: In total, 32 patients were identified, of whom 15 were diagnosed with BS and 17 with OEP. Initially, 11/32 (34.4%) were primarily treated endoscopically, 12/32 (37.8%) with surgery, and 8/32 (25.0%) with a combined treatment. Patients with BS had larger perforations (22.50 vs. 15.00 mm, Conclusions: BS and sepsis at admission are risk factors for a complicated course. Endoscopy is the first choice for diagnosis and initial treatment. Patients with mediastinal gross contamination or large defects usually need surgical intervention, which should not be delayed.

Indexed as

Boerhaave syndromeEndoVACesophageal perforationesophagectomyEVT

Identifiers

PMID41104176
PMCPMC12521197

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.