Evidence map›Paper›PMID 41104138›Full record

ArticleFrontiers in cellular and infection microbiology2025

Galectin-8 deficiency promotes chronic splenomegaly persistence in Chagas disease.

Adriano Bertelli, Juan Ignacio Saborit, Cristian Gabriel Beccaria, Laura Vanagas, Sergio Oscar Angel, Oscar Campetella, Adriana Gruppi, María Susana Leguizamón

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adriano Bertelli *Instituto de Investigaciones Biotecnológicas (IIBio), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín (UNSAM), Buenos Aires, Argentina.
Juan Ignacio Saborit *Instituto de Investigaciones Biotecnológicas (IIBio), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín (UNSAM), Buenos Aires, Argentina.
Cristian Gabriel Beccaria *Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina.
Laura VanagasInstituto de Investigaciones Tecnológicas de Chascomús (INTECH), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín (UNSAM), Buenos Aires, Argentina.
Sergio Oscar AngelInstituto de Investigaciones Tecnológicas de Chascomús (INTECH), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín (UNSAM), Buenos Aires, Argentina.
Oscar CampetellaInstituto de Investigaciones Biotecnológicas (IIBio), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín (UNSAM), Buenos Aires, Argentina.
Adriana GruppiCentro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina.
María Susana LeguizamónInstituto de Investigaciones Biotecnológicas (IIBio), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Escuela de Bio y Nanotecnologías (EByN), Universidad Nacional de San Martín (UNSAM), Buenos Aires, Argentina.

Funding

Role in pathogenesis and parasite cell biology of the trans-sialidase from Trypanosoma cruzi, the agent of Chagas DiseaseR01AI104531 · NIAID · INSTITUTE/RESEARCH/BIOTECHNOLOGY FDN · PI CAMPETELLA, OSCAR EDUARDO · 2014 to 2023
$1.3M
Antibody-secreting cells in the regulation of T cell response to Trypanosoma cruziR01AI116432 · NIAID · NATIONAL RESEARCH COUNCIL OF ARGENTINA · PI ADRIANA GRUPPI · 2015 to 2026
$1.3M
NIAID NIH HHS R01 AI104531NIAID NIH HHS R01 AI116432
6 · The paper itself

Abstract

Galectins (Gals) are mammalian lectins with affinity for

Indexed as

Chagas DiseaseGalectinsSplenomegalyTrypanosoma cruziAnimalsB-LymphocytesCell ProliferationChronic DiseaseDisease Models, AnimalLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutParasite LoadParasitemiaSpleengalectin-8, mouseGalectinsChagas diseaseGalectin-8inflammationsplenomegalyTrypanosoma cruzi

Identifiers

PMID41104138
PMCPMC12521124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.