ReviewFrontiers in genetics2025
Recent advances of DNA methylation in osteonecrosis of the femoral head.
Review in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Epigenetic dysregulation in osteonecrosis of the femoral head: a critical review of DNA methylation, histone modifications, and clinical translation.Journal of orthopaedic surgery and research · 2026Review
- Research advancements in DNA methylation pertaining to ankylosing spondylitis.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
DNA methylation, maintenance, and demethylation are essential for maintaining normal physiological functions. Recent studies have revealed that DNA methylation plays a crucial role in the progression of osteonecrosis of the femoral head. DNA methylation regulates the differentiation direction of bone marrow mesenchymal stem cells, affects angiogenesis, and is involved in the proliferation and apoptosis of osteocytes, holding significant potential for early diagnosis and treatment of the disease. This paper introduces the concept and process of DNA methylation, with an emphasis on its molecular mechanisms in osteonecrosis of the femoral head. Furthermore, we propose that modulating different states of DNA methylation, such as inhibiting the function of DNA methyltransferases to induce DNA demethylation, could impact the disease progression of osteonecrosis of the femoral head, offering new insights for its treatment.
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