Evidence map›Paper›PMID 41104024›Full record

ArticlePulmonary circulation2025

Platelet-Macrophage Aggregates in Remodeled Vessels of Patients With Pulmonary Arterial Hypertension.

Christine L Farrell, Mariah Jordan, Janelle N Posey, Kimberly R Jordan, Aneta Gandjeva, Eva S Nozik, Kurt R Stenmark, Rubin M Tuder, Brian B Graham, Cassidy A Delaney

Abstract readLetter
In one paragraph

Article in Pulmonary circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. The emerging role of integrin signaling in pulmonary vascular disease.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christine L FarrellCardiovascular Pulmonary Research Laboratories, Department of Pediatrics University of Colorado Anschutz Medical Campus Aurora Colorado USA.ORCID https://orcid.org/0009-0007-8369-8721
Mariah JordanCardiovascular Pulmonary Research Laboratories, Department of Pediatrics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Janelle N PoseyCardiovascular Pulmonary Research Laboratories, Department of Pediatrics University of Colorado Anschutz Medical Campus Aurora Colorado USA.ORCID https://orcid.org/0000-0002-2846-9260
Kimberly R JordanDepartment of Immunology & Microbiology University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Aneta GandjevaCardiovascular Pulmonary Research Laboratories, Department of Pediatrics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Eva S NozikCardiovascular Pulmonary Research Laboratories, Department of Pediatrics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Kurt R StenmarkCardiovascular Pulmonary Research Laboratories, Department of Pediatrics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Rubin M TuderCardiovascular Pulmonary Research Laboratories, Department of Pediatrics University of Colorado Anschutz Medical Campus Aurora Colorado USA.
Brian B GrahamDepartment of Medicine, Division of Pulmonary and Critical Care Medicine University of California San Francisco California USA.
Cassidy A DelaneyCardiovascular Pulmonary Research Laboratories, Department of Pediatrics University of Colorado Anschutz Medical Campus Aurora Colorado USA.

Funding

MULTIDISCIPLINARY RESPIRATORY DISEASES RESEARCH TRAININGT32HL007085 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ELLEN L BURNHAM, LISA A MAIER · 1985 to 2026
$21.6M
Role of Complement-Driven Pulmonary Vascular Inflammation in PHP01HL152961 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI DELANEY, CASSIDY A · 2020 to 2024
$14.1M
Investigating paclitaxel treatment in a pre-clinical model of Schistosoma-pulmonary hypertensionR01HL135872 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Brian Barkley Graham · 2017 to 2026
$5.1M
NHLBI NIH HHS P01 HL152961NHLBI NIH HHS R01 HL135872NHLBI NIH HHS T32 HL007085
6 · The paper itself

Abstract

Using lung immunohistochemistry and stereology, platelets were found to accumulate and co-localize with leukocytes, particularly monocytes, within the mural and adventitial space of remodeled vessels of patients with pulmonary arterial hypertension. The presumed signaling between these cell types invites further studies into the role of platelet-monocyte aggregates in pulmonary hypertension.

Indexed as

pulmonary hypertensionthromboinflammationvascular inflammation

Identifiers

PMID41104024
PMCPMC12521612

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.