ArticleCureus2025
Impact of Corrected Minute Ventilation on Mortality in Mechanically Ventilated Patients With COVID-19-Related Acute Respiratory Distress Syndrome: A Multicenter, Observational Study Using the J-RECOVER Registry Data.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background Corrected minute ventilation (VEcorr) has been proposed as a surrogate marker for dead space ventilation and may be associated with increased mortality in COVID-19-related acute respiratory distress syndrome (ARDS). However, prior studies have shown inconsistent results, and the mechanisms contributing to elevated VEcorr remain unclear. Methodology A multicenter, observational study was conducted using data from the J-RECOVER registry, including 335 adult patients with COVID-19-related ARDS who received invasive mechanical ventilation. VEcorr was calculated using the initial ventilator settings and arterial blood gas values. Multivariable logistic regression analysis was performed to assess the association between VEcorr and in-hospital mortality, adjusting for potential confounders. Results Higher VEcorr was independently associated with increased in-hospital mortality (odds ratio = 1.11; 95% confidence interval = 1.01-1.23; p = 0.039). Patients with a higher VEcorr also had higher levels of fibrin degradation products and Fibrosis-4 scores. In addition, a higher VEcorr was significantly associated with elevated PaCO
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