Evidence map›Paper›PMID 41103822›Full record

ReviewCureus2025

Long-Term Proton Pump Inhibitor Therapy and Risk of Gastric Atrophy and Precancerous Mucosal Changes: A Systematic Review.

Adeel Khalid, Bhavna Singla, Shivam Singla, Sunita Kumawat, Abdullah Abbas, Shaheem Ur Rehman, Prem Chand, Lachhmi Bai, Arif Tajammul

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adeel KhalidInternal Medicine, Kulhudhuffushi Regional Hospital, Kulhudhuffushi, MDV.
Bhavna SinglaInternal Medicine, Erie County Medical Center Health Campus, Buffalo, USA.
Shivam SinglaInternal Medicine, TidalHealth Peninsula Regional, Salisbury, USA.
Sunita KumawatInternal Medicine, Hackensack Meridian Ocean Medical Center, Brick, USA.
Abdullah AbbasInternal Medicine, Shaikh Zayed Hospital, Lahore, PAK.
Shaheem Ur RehmanInternal Medicine, Pakistan Air Force Hospital, Islamabad, PAK.
Prem ChandInternal Medicine, City Medical Centre, Kandhkot, PAK.
Lachhmi BaiInternal Medicine, Chandka Medical College, Karachi, PAK.
Arif TajammulInternal Medicine, Services Hospital Lahore, Lahore, PAK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review evaluated the association between long-term use of proton pump inhibitors (acid-suppressing medications) and the development of gastric atrophy and related precancerous mucosal changes. Six clinical trials involving a total of more than 1,100 patients with acid-peptic disorders were analyzed, encompassing diverse study designs, follow-up durations ranging from two to five years, and variable

Indexed as

gastric atrophygastroesophageal reflux diseasehelicobacter pyloriintestinal metaplasialong-term therapyproton pump inhibitors

Identifiers

PMID41103822
PMCPMC12521812

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.