Prevalence and clinical correlates of Peyronie's disease in patients with Dupuytren's disease: a cross-sectional study from a tertiary andrology center.

Background: Dupuytren's disease (DD) and Peyronie's disease (PD) are fibroproliferative disorders that may share common pathophysiological mechanisms. Aim: To determine the prevalence of PD among male patients diagnosed with DD and to investigate its clinical and laboratory correlates. Methods: This cross-sectional observational study was conducted at a tertiary academic center and included 101 male patients diagnosed with DD. All participants underwent structured andrological evaluation and were classified into PD and non-PD groups. Clinical and laboratory parameters-including demographic, metabolic, sexual function, and inflammatory markers-were compared between the groups. Statistical analyses included descriptive statistics, Chi-square or Fisher's exact tests for categorical variables, and Mann-Whitney U tests for continuous variables. Binary logistic regression was performed to identify independent predictors of concomitant PD. Outcomes: The primary outcome was the prevalence of PD among patients with DD. Secondary outcomes included associations between PD and clinical/laboratory features. Results: PD was significantly associated with bilateral Dupuytren's contracture (86.4% vs. 50.6%, Clinical Implications: Male patients with DD-especially those with bilateral hand involvement or poor glycemic control-may warrant consideration for opportunistic urological evaluation to identify concomitant PD. However, further research is needed to determine the impact of early detection on patient outcomes. Strengths and Limitations: This study is among the few to explore the prevalence and clinical correlates of PD in patients with DD, using a structured urological evaluation and comprehensive laboratory profiling. However, its cross-sectional design limits causal inference, and the single-center setting may affect the generalizability of the findings. Conclusion: PD is highly prevalent among patients with DD, especially those with bilateral contracture and poor glycemic control. These findings support a possible systemic fibrotic predisposition and highlight the value of integrated metabolic and sexual health assessment in this population.