Evidence map›Paper›PMID 41103812›Full record

ArticleF1000Research2025

Peripheral Blood Expression of MMPs and DNA Methylation-Related Genes in Women with Recurrent Spontaneous Abortion: A Case-Control Study.

Maryam Imani, Fateme Zare, Hossein Hadinedoushan, Fateme Rahmani, Farzaneh Fesahat

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In one paragraph

Article in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maryam ImaniReproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fateme ZareReproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hossein HadinedoushanReproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fateme RahmaniDepartment of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Farzaneh FesahatReproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.ORCID https://orcid.org/0000-0002-3743-4449

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recurrent spontaneous abortion (RSA) is one of the most common reproductive complications among women of childbearing age. Several factors-including genetic, anatomical, endocrine, infectious, environmental, and immunological causes-have been implicated in RSA. This study aimed to explore the potential association between RSA and the expression patterns of selected genes involved in critical biological processes related to pregnancy maintenance and miscarriage. Methods: The relative expression levels of Results: No significant differences in the mRNA expression levels of the target genes were observed between women with RSA and the control group. Conclusions: Our findings suggest that peripheral blood gene expression profiles of

Indexed as

Abortion, HabitualDNA MethylationMatrix MetalloproteinasesAdultCase-Control StudiesDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AFemaleHumansMatrix Metalloproteinase 2Matrix Metalloproteinase 9Methylenetetrahydrofolate Reductase (NADPH2)PregnancyYoung AdultDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT1 protein, humanDNMT3A protein, humanMatrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix MetalloproteinasesMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanRecurrent spontaneous abortion; DNA methyltransferases; matrix metallopeptidases; gene expression; peripheral blood.

Identifiers

PMID41103812
PMCPMC12521897

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