SynthesisFrontiers in medicine2025
The correlation between sarcopenia and osteoporosis in the elderly: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Comment on: "Effectiveness of High-Intensity Versus Low-To-Moderate-Intensity Resistance Training in Improving Muscle Strength and Bone Mineral Density in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials".Geriatrics & gerontology international · 2026Article
- Orthogeriatric Fracture Syndrome: A Large-Scale Bibliometric Analysis of a Proposed Concept for Cross-Disciplinary Awareness and Coordinated Care.Journal of clinical medicine · 2026Article
- Beyond Histology: Tensiomyography as an Integrated Measure of Muscle Function in Osteoporotic and Osteoarthritic Patients.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sarcopenia and osteoporosis, as two prevalent geriatric syndromes, synergistically elevate risks of falls, fractures, and disability in older adults. Despite shared pathophysiological mechanisms-including hormonal dysregulation, chronic inflammation, and attenuated mechanical loading. Existing studies have yet to establish consensus regarding the epidemiological association strength and interaction dynamics between sarcopenia and osteoporosis, particularly as heterogeneous characteristics-including sex, geographic region, and population subgroups-remain insufficiently characterized. This study aimed to quantitatively evaluate the sarcopenia-osteoporosis association in older adults through systematic review and meta-analysis of global observational studies, while analyzing the moderating effects of geographic location, sex, population characteristics, and diagnostic criteria on outcomes. Methods: We searched PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases until September 2024. Fourteen observational studies quantifying muscle mass/function and bone mineral density were included. Two investigators independently performed literature screening and data extraction. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Studies were meta-analyzed by Review Manager 5.4 and Stata 17.0. Results: A total of 14 studies ( Conclusion: Our meta-analysis demonstrates that sarcopenia significantly elevates osteoporosis susceptibility, with heterogeneous risk profiles across geographic regions and population subgroups. However, limitations inherent to the methodological quality and sample size of included studies necessitate validation through large-scale prospective cohort investigations.
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