ArticleFrontiers in medicine2025
GnRH agonist pretreatment in hormonal endometrial preparation: a comparison of two protocols for frozen embryo transfer outcomes.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Association of GnRH Agonist Pretreatment with Reproductive Outcomes in Women ≥35 years with Diminished Ovarian Reserve Undergoing Frozen Embryo Transfer: A Large Retrospective Cohort Study.International journal of women's health · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The aim of this study was to compare the effects of different endometrial treatment regimens on the outcome of frozen embryo transfer (FET). Methods: A retrospective analysis of 1,454 FET cycles was conducted. Subgroups were stratified by primary infertility diagnosis (tubal factor, polycystic ovary syndrome (PCOS), and endometriosis) and by the number of embryos transferred. Multivariable logistic regression was employed to identify factors influencing live birth. Results: Our study found that endometrial thickness on the day of embryo transfer was thicker in the gonadotropin-releasing hormone agonist (GnRHa)-hormone replacement therapy (HRT) group compared to the HRT group ( Conclusion: The GnRHa-HRT significantly improves live birth rates compared to the conventional HRT in single-embryo transfer cycles. Downregulation protocols may be a priority for patients with endometriosis and single embryo transfer. For patients with PCOS and tubal factors, the HRT program is more cost-effective and takes less time to achieve pregnancy. These findings provide evidence-based guidance for individualized endometrial preparation regimen selection in FET cycles, though the retrospective design and lack of long-term follow-up limit the generalizability. Future prospective randomized controlled trials with larger sample sizes are warranted to validate these conclusions.
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