Evidence map›Paper›PMID 41103682›Full record

ArticleNature synthesis2024

Applications of synthetic polymers directed toward living cells.

Anqi Zhang, Spencer Zhao, Jonathan Tyson, Karl Deisseroth, Zhenan Bao

Abstract read
In one paragraph

Article in Nature synthesis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
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  12. Bacteria-Mediated Intracellular Radical Polymerizations.Journal of the American Chemical Society · 2025
    Article
  13. Review
  14. Article
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  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anqi ZhangDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Spencer ZhaoDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Jonathan TysonDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.
Karl DeisserothDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Zhenan BaoDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.

Funding

American Heart Association-American Stroke Association 23POST1018301
6 · The paper itself

Abstract

Cells execute remarkable functions using biopolymers synthesized from natural building blocks. Engineering cells to leverage the vast array of synthesizable abiotic polymers could provide enhanced or entirely new cellular functions. In this review, we discuss the applications of in situ synthesized abiotic polymers in three distinct domains: intracellular polymerization, cell surface polymerization, and extracellular polymerization. These advances have led to novel applications in various areas, such as cancer therapy, cell imaging, cellular activity manipulation, cell protection, and electrode assembly. Examples of these synthetic approaches can be applied across all domains of life, ranging from microbes and cultured mammalian cells to plants and animals. Finally, we discuss challenges and future opportunities in this emerging field, which could enable new synthetic approaches to influence biological processes and functions.

Identifiers

PMID41103682
PMCPMC12524119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.