ReviewFrontiers in endocrinology2025
The impact, mechanisms and prevention strategies of environmental endocrine disruptors on male reproductive health.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Integrated multi-omics, machine learning, network toxicology, and molecular docking reveal potential mechanisms underlying methyl 4-hydroxybenzoate-associated breast cancer.Molecular diversity · 2026Article
- Review
- The Global Decline in Sperm Count and Testosterone Levels: Trends, Mechanisms, and Environmental Drivers.Antioxidants (Basel, Switzerland) · 2026Review
- Environmental endocrine disruptors in cardio-oncology: emerging modifiers of cardiovascular vulnerability in patients with cancer.Cardio-oncology (London, England) · 2026Review
- Endocrine Disruption and Male Fertility.Current environmental health reports · 2026Review
- Environmental estrogens and animal reproductive health: mechanisms, biomarkers, and intervention approaches.Journal of animal science and biotechnology · 2026Review
- Article
- Neonicotinoids and the Androgen Receptor: Structural Dynamics and Potential Signaling Disruption.Biology · 2026Article
- Emerging peptide and neuroendocrine strategies for TRT-induced reproductive suppression and functional male hypogonadism: a narrative review.Frontiers in reproductive health · 2026Review
- Endocrine-disrupting chemicals in male reproductive health: exposure risks, reproductive toxicity and emerging perspectives.Frontiers in endocrinology · 2026Review
- Exploratory Review on Male Fertility Potential of Acetyl-Eugenol: Mechanistic Insights, Experimental Evidence, and Therapeutic Prospects.Journal of experimental pharmacology · 2026Review
- Lambda-cyhalothrin and male reproductive dysfunction: neurotoxicity, hypogonadism, erectile dysfunction, and infertility.Frontiers in public health · 2026Review
- The Threat of Micro-/Nanoplastics to Male Fertility: A Review of the Data and the Importance of Future Research.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Environmental endocrine disruptors (EEDs) including heavy metals, plasticizers, and persistent organic pollutants have been increasingly linked to declining male reproductive health globally. While epidemiological associations are well-established, the underlying molecular mechanisms and long-term consequences require systematic evaluation. Objectives: This review synthesizes current evidence on EED impacts on male reproductive health, focusing on molecular mechanisms, population-based evidence, transgenerational effects, and intervention strategies. Methods: We conducted comprehensive literature searches across PubMed, Web of Science, and Scopus (2019-2024) to identify peer-reviewed studies on EED reproductive toxicity, including mechanistic investigations, epidemiological studies, and intervention research. Results: EEDs disrupt male reproduction through multiple pathways: androgen and estrogen receptor interference, oxidative stress induction, mitochondrial dysfunction, and epigenetic modifications. Population studies demonstrate consistent associations between EED exposure and reduced sperm quality, with effect sizes varying by exposure level and chemical type. Animal studies provide compelling evidence for transgenerational inheritance of reproductive dysfunction through epigenetic mechanisms, though human evidence remains limited. Workplace protection measures, environmental remediation, and policy interventions show promise but require broader implementation. Conclusions: EEDs pose significant threats to male reproductive health through complex, interconnected mechanisms. While substantial progress has been made in understanding these effects, critical gaps remain in mixture toxicology, low-dose effects, and transgenerational impacts in humans. Enhanced biomonitoring, mechanism-based interventions, and strengthened regulatory frameworks are essential for protecting current and future reproductive health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.