ArticleFrontiers in endocrinology2025
Cholesterol, high-density lipoprotein, and glucose index is associated with renal survival in patients with IgA nephropathy.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Association Between Cholesterol-HDL-Glucose Index and Stroke Risk in Middle-Aged and Elderly Adults Without Diabetes: Evidence From Two National Cohort Studies.Cardiology research · 2026Article
- Association of the CHG Index with the onset, progression, and prognosis of cardiovascular-kidney-metabolic syndrome: findings from two large prospective cohorts.Diabetology & metabolic syndrome · 2026Article
- The prognostic significance of cholesterol, high-density lipoprotein and glucose (CHG) index in evaluating all-cause mortality risk in metabolic dysfunction-associated steatotic liver disease (MASLD) individuals: evidence from two cohort studies.Cardiovascular diabetology · 2026Article
- A novel glucose-lipid metabolism-related indicator and its association with metabolic dysfunction-associated fatty liver disease: a cross-sectional study based on a health check-up population.Frontiers in endocrinology · 2026Article
- Association of cholesterol, high-density lipoprotein, and glucose (CHG) index with chronic kidney disease in Chinese community adults: findings from the REACTION study.Frontiers in nutrition · 2026Article
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Abstract
Background: The cholesterol, high-density lipoprotein, and glucose (CHG) index has emerged as a novel biomarker for insulin resistance (IR) and metabolic syndrome (MS). However, its prognostic role in IgA nephropathy (IgAN) remains underexplored. This study investigated the association between the CHG index and IgAN and aimed to clarify the importance of the CHG index in evaluating the prognosis of IgAN. Methods: This single-centre retrospective study included 1791 patients with biopsy-confirmed IgAN who had more than 12 months of follow-up from October 2014 to September 2023. The optimal CHG index cut-off for renal endpoints was determined using receiver operating characteristic (ROC) analysis. Associations were assessed via correlation analysis, Cox regression, and Kaplan-Meier survival analysis. Results: Patients were stratified into three baseline CHG index tertiles. High baseline CHG index was correlated with adverse clinicopathological features and reduced renal survival (Kaplan-Meier, log-rank=26.51; P<0.001). Correlation analyses revealed that the CHG index was positively associated with tubular atrophy/interstitial fibrosis, as well as intimal thickening and hyaline degeneration of renal arteries (P<0.001). The optimal CHG index cut-off for renal survival was 5.29 (sensitivity=63.1%, specificity=63.0%, AUC = 0.646), and patients were divided into a low group (CHG index ≤ 5.29; n=1,096) and a high group (CHG index >5.29; n=695). Subgroup analysis revealed that elevated CHG indices had a more pronounced prognostic value for renal outcomes in subgroups of patients with a BMI ≤ 24.9, a 24-hour urine protein level ≤ 3.5 g, an estimated glomerular filtration rate (eGFR)≤45 mL/min/1.73m², and an Oxford renal pathology classification (MEST-C)T0. Multivariate Cox regression analysis demonstrated that elevated CHG indices were significantly associated with worse renal outcomes in patients with IgAN (adjusted HR: 1.842; 95% CI: 1.044-3.249; P = 0.035). Conclusion: Elevated CHG index is an independent risk factor for predicting renal prognosis in IgAN. Compared with patients with low CHG indices, those with CHG indices > 5.29 have an 84.2% greater risk of poor renal outcomes.
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