ArticleFrontiers in endocrinology2025
Alterations of oral microbiota and cytokines profile in children and young adults with type 1 diabetes.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Type 1 diabetes (T1D) is a chronic autoimmune disease caused by the destruction of pancreatic β cells. Although T1D is characterized by an increased susceptibility to oral inflammatory diseases, studies investigating the relationship between oral microbiota, oral inflammation, and T1D remain limited and often report conflicting results. Methods: In this work, we compared both oral microbiota composition and cytokines profile of 75 children and young adults with T1D and 79 healthy controls (HC), using 16S rRNA gene targeted sequencing and magnetic bead-based multiplex immunoassays. Results: We found significant changes in both alpha and beta diversity, with a decrease in species richness (p-value<0.001) and an increase in species evenness (p-value<0.001). At the genus level, T1D participants exhibited a lower abundance of Discussion: Overall, our findings suggest that in subjects with T1D changes in the oral microbiota composition may contribute to modify the immune response toward alteration of the cytokine profile.
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