ArticleReproductive medicine and biology
BRD4 Inhibitor Alleviates Recurrent Spontaneous Abortion via Regulating BRD4/STAT3/IL-17A Axis to Decrease the Th17 Cell Differentiation.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- BRD4 Inhibitor Alleviates Recurrent Spontaneous Abortion via Regulating BRD4/STAT3/IL-17A Axis to Decrease the Th17 Cell Differentiation.Reproductive medicine and biologyArticle
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Purpose: Recurrent spontaneous abortion (RSA) is an abnormal phenomenon that severely affects women's quality of life. Inhibiting Th17 cell differentiation can alleviate RSA. This research explored the mechanism by which BRD4 Inhibitor (BETi) suppressed the differentiation of Th17 cells to mitigate RSA. Methods: PBMCs and Naive CD4 Results: The Th17/Treg ratio and the expression levels of BRD4, STAT3, and IL-17A were elevated, while STAT5b expression was down-regulated in RSA patients. BETi or STAT3 knockdown decreased the differentiation of Th17 cells and lipid synthesis. BRD4 inhibition impaired STAT3-mediated IL-17A transcription. BETi inhibited embryo absorption in mice. Conclusions: BETi inhibits the differentiation of Th17 cells in RSA by reducing the STAT3-mediated IL-17A expression.
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