Evidence map›Paper›PMID 41103415›Full record

ArticleFrontiers in immunology2025

Identification of novel amino acid variants in the Han Chinese population that impair toll-like receptor 4 signaling and confer hyporesponsiveness to lipopolysaccharide.

Bin Zhou, Zhaoying Lv, Ruijuan Zu, Jianbo Liu, Yuting Yang, Zongguang Zhou, Yuan Li

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bin ZhouLaboratory of Digestive Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
Zhaoying LvLaboratory of Digestive Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
Ruijuan ZuLaboratory of Digestive Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
Jianbo LiuDivision of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yuting YangDivision of Gastrointestinal Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zongguang ZhouLaboratory of Digestive Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
Yuan LiLaboratory of Digestive Surgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Severe acute pancreatitis (SAP), characterized by life-threatening inflammation and multiorgan failure, involves Toll-like receptor 4 (TLR4)-mediated hyperinflammation. This study investigates TLR4 variants' impact on disease severity. Methods: Sanger sequencing was performed in a Han Chinese cohort of patients with acute pancreatitis to screen for Results: Five novel missense variants in Couclusion: We characterized novel

Indexed as

East Asian PeopleLipopolysaccharidesPancreatitisSignal TransductionToll-Like Receptor 4AdultAnimalsChinaFemaleHEK293 CellsHumansMaleMiceMiddle AgedMutation, MissenseLipopolysaccharidesTLR4 protein, humanToll-Like Receptor 4lipopolysaccharidemissense variantNF-kappa Bsevere acute pancreatitistoll-like receptor 4

Identifiers

PMID41103415
PMCPMC12521208

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.