Evidence map›Paper›PMID 41103411›Full record

ArticleFrontiers in immunology2025

Case report: Spontaneous remission of severe aplastic anemia mediated by mutant hematopoietic stem cells evading T-cell attack.

Kohei Shiroshita, Yoshitaka Zaimoku, Himari Kudo, Naoshi Obara, Kazuyoshi Hosomichi, Yui Kano, Miku Kobayashi, Eriko Morishita, Hiroyuki Takamatsu, Takaaki Toyama and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kohei Shiroshita *Department of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital, Tokyo, Japan.
Yoshitaka Zaimoku *Department of Hematology, Kanazawa University, Kanazawa, Japan.
Himari KudoDepartment of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital, Tokyo, Japan.
Naoshi ObaraDepartment of Medical Science, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Kazuyoshi HosomichiLaboratory of Computational Genomics, School of Life Science, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Yui KanoDepartment of Clinical Laboratory Science, School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Miku KobayashiDepartment of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Eriko MorishitaDepartment of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
Hiroyuki TakamatsuDepartment of Hematology, Kanazawa University, Kanazawa, Japan.
Takaaki ToyamaDepartment of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital, Tokyo, Japan.
Shinji NakaoDepartment of Hematology, Kanazawa University, Kanazawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T-cell-mediated severe aplastic anemia (SAA) is typically fatal without prompt hematopoietic stem cell transplantation or intensive immunosuppressive therapy. Although rare cases of spontaneous remission have been reported, the underlying mechanisms remain poorly understood. A 24-year-old woman was incidentally found to have mild pancytopenia during a routine workplace health checkup. Over the subsequent 12 months, her pancytopenia gradually worsened, resulting in exertional dyspnea, purpura, and a diagnosis of SAA. Remarkably, her blood counts began to improve spontaneously 11 days after the diagnosis without any treatment or transfusions. She no longer met the criteria for SAA by day 27 and achieved complete hematologic normalization within three months. At 22 months, flow cytometry and targeted sequencing revealed that 69% of her granulocytes lacked the

Indexed as

Anemia, AplasticHematopoietic Stem CellsMutationT-LymphocytesFemaleHumansMembrane ProteinsRemission, SpontaneousYoung AdultMembrane Proteinsphosphatidylinositol glycan-class A proteinchromosome 6p loss of heterozygosityHLA lossimmune escapeparoxysmal nocturnal hemoglobinuriasevere aplastic anemiasomatic mutationspontaneous remission

Identifiers

PMID41103411
PMCPMC12521157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.