Evidence map›Paper›PMID 41103388›Full record

ArticleFood chemistry: X2025

Interaction between hyaluronic acid and phospholipid bilayer and its influence on stability and bioavailability of luteolin-loaded liposomes.

Le Cheng, Ming Zhang, Lin Dong, Yifei Wang, Jianguo Dong, Fang Wu, Chenyan Zheng, Yumeng Ma, Zihan Wang, Ran Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food chemistry: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. DualAntioxidants (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Le ChengKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, 100193 Beijing, China.
Ming ZhangSchool of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Lin DongKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, 100193 Beijing, China.
Yifei WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, 100193 Beijing, China.
Jianguo DongKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, 100193 Beijing, China.
Fang WuKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, 100193 Beijing, China.
Chenyan ZhengKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, 100193 Beijing, China.
Yumeng MaKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, 100193 Beijing, China.
Zihan WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, 100193 Beijing, China.
Ran WangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, 100193 Beijing, China.
Yixuan LiKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, 100193 Beijing, China.
Bing FangKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, 100193 Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The poor solubility of luteolin limits its food applications, and while liposomes offer a potential delivery solution, their phospholipid bilayer membranes are unstable. To overcome these dual challenges, this study developed hyaluronic acid (HA)-coated luteolin liposomes (HA-LUT-lips). HA-LUT-lips exhibited a core-shell structure, high encapsulation efficiency, and good dispersibility. Fourier transform infrared spectroscopy (FTIR) confirmed HA interacted with liposomes via hydrogen bonds, while Raman spectroscopy (RS) showed HA reduced membrane fluidity and enhanced lipid lateral packing. Thermogravimetric (TG) analysis and differential scanning calorimetry (DSC) revealed that HA-LUT-lips were more thermally stable than LUT-lips. HA coating also enhanced ionic strength and storage stability, slowing luteolin release during simulated digestion. HA coating can resist the oxidation of liposomes and delay the leakage of luteolin. These findings suggest HA-coated liposomes were a promising delivery system for luteolin in functional foods and nutritional enhancers.

Indexed as

Hyaluronic acidInteractionsLiposomesLuteolinOxidationStability

Identifiers

PMID41103388
PMCPMC12524136

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.